* Inductively coupled plasma mass-spectrometric determination of platinum in excretion products of client-owned pet dogs.
- Residues of antineoplastic drugs in canine excretion products may represent exposure risks to veterinary personnel, owners of pet dogs and other animal care-takers. The aim of this study was to measure the extent and duration of platinum (Pt) excretion in pet dogs treated with carboplatin. Samples were collected before and up to 21 days after administration of carboplatin. We used validated, ultra-sensitive, inductively coupled plasma-mass spectrometry assays to measure Pt in canine urine, faeces, saliva, sebum and cerumen. Results showed that urine is the major route of elimination of Pt in dogs. In addition, excretion occurs via faeces and saliva, with the highest amounts eliminated during the first 5 days. The amount of excreted Pt decreased over time but was still quantifiable at 21 days after administration of carboplatin. In conclusion, increased Pt levels were found in all measured excretion products up to 21 days after administration of carboplatin to pet dogs, with urine as the main route of excretion. These findings may be used to further adapt current veterinary guidelines on safe handling of antineoplastic drugs and treated animals.
=>1.超えて, 一面に, 移って, 始めから終わりまで, 終わって, を支配して, の間, しながら, 倒れて, の上に,
を覆って, を越えて, の向こう側に, より多く, 2.もう一度, 繰り返して
Overview of noun over
The noun over has 1 sense (no senses from tagged texts)
1. over -- ((cricket) the division of play during which six balls are bowled at the batsman by one
player from the other team from the same end of the pitch)
Overview of adj over
The adj over has 1 sense (first 1 from tagged texts)
1. (21) complete, concluded, ended, over, all over, terminated -- (having come or been brought to a
conclusion; "the harvesting was complete"; "the affair is over, ended, finished"; "the abruptly
terminated interview")
Overview of adv over
The adv over has 5 senses (first 3 from tagged texts)
1. (23) over -- (at or to a point across intervening space etc.; "come over and see us some time";
"over there")
2. (2) over -- (throughout an area; "he is known the world over")
3. (1) over, o'er -- (throughout a period of time; "stay over the weekend")
4. over -- (beyond the top or upper surface or edge; forward from an upright position; "a roof that
hangs over";)
5. all over, over -- (over the entire area; "the wallpaper was covered all over with flowers"; "she
ached all over"; "everything was dusted over with a fine layer of soot")
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