ELIZA

return kwic search for over out of >500 occurrences
295512 occurrences (No.81 in the rank) during 5 years in the PubMed. [no cache] 500 found

220) Immature spines (filopodia, long) exhibited the greatest sensitivity (1.5- to 3-fold) to irradiation, while more mature spines (mushroom) were more resistant to changes over a 1-month post-irradiation timeframe.

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PMID:24446074 DOI:10.1007/s00429-014-0709-9

2015 Brain structure & function

* Persistent changes in neuronal structure and synaptic plasticity caused by proton irradiation.

- Cranial radiotherapy is used routinely to control the growth of primary and secondary brain tumors, but often results in serious and debilitating cognitive dysfunction. In part due to the beneficial dose depth distributions that may spare normal tissue damage, the use of protons to treat CNS and other tumor types is rapidly gaining popularity. Astronauts exposed to lower doses of protons in the space radiation environment are also at risk for developing adverse CNS complications. To explore the consequences of whole body proton irradiation, mice were subjected to 0.1 and 1 Gy and analyzed for morphometric changes in hippocampal neurons 10 and 30 days following exposure. Significant dose-dependent reductions (~33 %) in dendritic complexity were found, when dendritic length, branching and area were analyzed 30 days after exposure. At equivalent doses and times, significant reductions in the number (~30 %) and density (50-75 %) of dendritic spines along hippocampal neurons of the dentate gyrus were also observed. Immature spines (filopodia, long) exhibited the greatest sensitivity (1.5- to 3-fold) to irradiation, while more mature spines (mushroom) were more resistant to changes over a 1-month post-irradiation timeframe. Irradiated granule cell neurons spanning the subfields of the dentate gyrus showed significant and dose-responsive reductions in synaptophysin expression, while the expression of postsynaptic density protein (PSD-95) was increased significantly. These findings corroborate our past work using photon irradiation, and demonstrate for the first time, dose-responsive changes in dendritic complexity, spine density and morphology and synaptic protein levels following exposure to low-dose whole body proton irradiation.

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[frequency of next (right) word to over]

(1)145 the	(8)6 their	(15)3 four	(22)2 40
(2)70 time	(9)4 6	(16)3 longer	(23)2 OP
(3)67 a	(10)4 in	(17)3 other	(24)2 another
(4)12 time,	(11)3 1	(18)3 placebo	(25)2 collagen)
(5)9 of	(12)3 12	(19)2 2	(26)2 left
(6)7 and	(13)3 24	(20)2 30	(27)2 long
(7)6 an	(14)3 65	(21)2 4	(28)2 settlement

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--- WordNet output for over --- =>1.超えて, 一面に, 移って, 始めから終わりまで, 終わって, を支配して, の間, しながら, 倒れて, の上に, を覆って, を越えて, の向こう側に, より多く, 2.もう一度, 繰り返して Overview of noun over The noun over has 1 sense (no senses from tagged texts) 1. over -- ((cricket) the division of play during which six balls are bowled at the batsman by one player from the other team from the same end of the pitch) Overview of adj over The adj over has 1 sense (first 1 from tagged texts) 1. (21) complete, concluded, ended, over, all over, terminated -- (having come or been brought to a conclusion; "the harvesting was complete"; "the affair is over, ended, finished"; "the abruptly terminated interview") Overview of adv over The adv over has 5 senses (first 3 from tagged texts) 1. (23) over -- (at or to a point across intervening space etc.; "come over and see us some time"; "over there") 2. (2) over -- (throughout an area; "he is known the world over") 3. (1) over, o'er -- (throughout a period of time; "stay over the weekend") 4. over -- (beyond the top or upper surface or edge; forward from an upright position; "a roof that hangs over";) 5. all over, over -- (over the entire area; "the wallpaper was covered all over with flowers"; "she ached all over"; "everything was dusted over with a fine layer of soot") --- WordNet end ---