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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for over out of >500 occurrences
295512 occurrences (No.81 in the rank) during 5 years in the PubMed. [no cache] 500 found
236) The results showed that levothyroxine sodium samples degraded significantly over a 32-day test period when subjected to dry conditions in the presence of molecular oxygen.
--- ABSTRACT ---
PMID:24295156 DOI:10.3109/10837450.2013.862635
2015 Pharmaceutical development and technology
* Impact of hydration state and molecular oxygen on the chemical stability of levothyroxine sodium.
- Levothyroxine sodium is an important medication used primarily for treating patients with hypothyroidism. Levothyroxine sodium tablets have been recalled many times since their 1955 introduction to the US market. These recalls resulted from the failure of lots to meet their content uniformity and potency specifications. The purpose of this study is to test the hypothesis that the chemical stability of levothyroxine sodium pentahydrate is compromised upon exposing the dehydrated substance to molecular oxygen. The impact of temperature, oxygen and humidity storage conditions on the stability of solid-state levothyroxine sodium was examined. After exposure to these storage conditions for selected periods of time, high performance liquid chromatography (HPLC) was used to quantify the formation of impurities. The results showed that levothyroxine sodium samples degraded significantly over a 32-day test period when subjected to dry conditions in the presence of molecular oxygen. However, dehydrated samples remained stable when oxygen was removed from the storage chamber. Furthermore, hydrated samples were stable in the presence of oxygen and in the absence of oxygen. These results reveal conditions that will degrade levothyroxine sodium pentahydrate and elucidate measures that can be taken to stabilize the drug substance.
--- ABSTRACT END ---
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[frequency of next (right) word to over]
(1)145 the (8)6 their (15)3 four (22)2 40
(2)70 time (9)4 6 (16)3 longer (23)2 OP
(3)67 a (10)4 in (17)3 other (24)2 another
(4)12 time, (11)3 1 (18)3 placebo (25)2 collagen)
(5)9 of (12)3 12 (19)2 2 (26)2 left
(6)7 and (13)3 24 (20)2 30 (27)2 long
(7)6 an (14)3 65 (21)2 4 (28)2 settlement

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--- WordNet output for over --- =>1.超えて, 一面に, 移って, 始めから終わりまで, 終わって, を支配して, の間, しながら, 倒れて, の上に, を覆って, を越えて, の向こう側に, より多く, 2.もう一度, 繰り返して Overview of noun over The noun over has 1 sense (no senses from tagged texts) 1. over -- ((cricket) the division of play during which six balls are bowled at the batsman by one player from the other team from the same end of the pitch) Overview of adj over The adj over has 1 sense (first 1 from tagged texts) 1. (21) complete, concluded, ended, over, all over, terminated -- (having come or been brought to a conclusion; "the harvesting was complete"; "the affair is over, ended, finished"; "the abruptly terminated interview") Overview of adv over The adv over has 5 senses (first 3 from tagged texts) 1. (23) over -- (at or to a point across intervening space etc.; "come over and see us some time"; "over there") 2. (2) over -- (throughout an area; "he is known the world over") 3. (1) over, o'er -- (throughout a period of time; "stay over the weekend") 4. over -- (beyond the top or upper surface or edge; forward from an upright position; "a roof that hangs over";) 5. all over, over -- (over the entire area; "the wallpaper was covered all over with flowers"; "she ached all over"; "everything was dusted over with a fine layer of soot") --- WordNet end ---