* Physiological correspondence dictates cortical long-term potentiation and depression by thalamic induction.
- The auditory cortex exhibits frequency-specific plasticity over a life cycle. Although thalamocortical long-term potentiation (LTP) and depression (LTD) are components of a widely held model underlying the receptive field (RF) plasticity of cortical neurons, the model lacks direct supporting evidence. We show here that conventional high-frequency tetanic stimulation (TS) of the auditory thalamus induced long-term changes in cortical field excitatory postsynaptic potentials, including both LTP and LTD, in mice. Thalamic TS induced LTP when the stimulated thalamic and recorded cortical neurons were tuned to the same frequency and induced LTD when they were tuned to different frequencies. The thalamocortical LTP was N-methyl-d-aspartate-dependent, but the LTD also involved cortical γ-amino-butyric acidergic inhibition. Notably, the frequency-specificity of cortical LTP/LTD was in accordance with the frequency-specific plasticity of spike-based RFs of cortical neurons. Our results suggest that cortical LTP and LTD induced by thalamic induction can be a consequence of identical stimuli, occur in an input-specific manner, and account for frequency-specific remodeling of RFs of auditory cortical neurons.
=>1.超えて, 一面に, 移って, 始めから終わりまで, 終わって, を支配して, の間, しながら, 倒れて, の上に,
を覆って, を越えて, の向こう側に, より多く, 2.もう一度, 繰り返して
Overview of noun over
The noun over has 1 sense (no senses from tagged texts)
1. over -- ((cricket) the division of play during which six balls are bowled at the batsman by one
player from the other team from the same end of the pitch)
Overview of adj over
The adj over has 1 sense (first 1 from tagged texts)
1. (21) complete, concluded, ended, over, all over, terminated -- (having come or been brought to a
conclusion; "the harvesting was complete"; "the affair is over, ended, finished"; "the abruptly
terminated interview")
Overview of adv over
The adv over has 5 senses (first 3 from tagged texts)
1. (23) over -- (at or to a point across intervening space etc.; "come over and see us some time";
"over there")
2. (2) over -- (throughout an area; "he is known the world over")
3. (1) over, o'er -- (throughout a period of time; "stay over the weekend")
4. over -- (beyond the top or upper surface or edge; forward from an upright position; "a roof that
hangs over";)
5. all over, over -- (over the entire area; "the wallpaper was covered all over with flowers"; "she
ached all over"; "everything was dusted over with a fine layer of soot")
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