ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for over out of >500 occurrences
295512 occurrences (No.81 in the rank) during 5 years in the PubMed. [no cache]
500 found
298) Cells exposed to Pb(2+) also increased production of c-Jun protein, a component of AP1, and over-expression of c-Jun enhanced activation of the gastrin promoter.
* Pb2+ induces gastrin gene expression by extracellular signal-regulated kinases 1/2 and transcription factor activator protein 1 in human gastric carcinoma cells.
- Divalent lead ions (Pb(2+) ) are toxic environmental pollutants known to cause serious health problems in humans and animals. Absorption of Pb(2+) from air, water, and food takes place in the respiratory and digestive tracts. The ways in which absorbed Pb(2+) affects cell physiology are just beginning to be understood at the molecular level. Here, we used reverse transcription PCR and Western blotting to analyze cultures of human gastric carcinoma cells exposed to 10 μM lead nitrate. We found that Pb(2+) induces gastrin hormone gene transcription and translation in a time-dependent manner. Promoter deletion analysis revealed that activator protein 1 (AP1) was necessary for gastrin gene transcription in cells exposed to Pb(2+) . MitogIen-activated protein kinase (MAPK)/ERK kinase inhibitor PD98059 suppressed the Pb(2+) -induced increase in messenger RNA. Epidermal growth factor receptor (EGFR) inhibitors AG1478 and PD153035 reduced both transcription and phosphorylation by extracellular signal-regulated kinase (ERK1/2). Cells exposed to Pb(2+) also increased production of c-Jun protein, a component of AP1, and over-expression of c-Jun enhanced activation of the gastrin promoter. In sum, the findings suggest the EGFR-ERK1/2-AP1 pathway mediates the effects of Pb(2+) on gastrin gene activity in cell culture.
=>1.超えて, 一面に, 移って, 始めから終わりまで, 終わって, を支配して, の間, しながら, 倒れて, の上に,
を覆って, を越えて, の向こう側に, より多く, 2.もう一度, 繰り返して
Overview of noun over
The noun over has 1 sense (no senses from tagged texts)
1. over -- ((cricket) the division of play during which six balls are bowled at the batsman by one
player from the other team from the same end of the pitch)
Overview of adj over
The adj over has 1 sense (first 1 from tagged texts)
1. (21) complete, concluded, ended, over, all over, terminated -- (having come or been brought to a
conclusion; "the harvesting was complete"; "the affair is over, ended, finished"; "the abruptly
terminated interview")
Overview of adv over
The adv over has 5 senses (first 3 from tagged texts)
1. (23) over -- (at or to a point across intervening space etc.; "come over and see us some time";
"over there")
2. (2) over -- (throughout an area; "he is known the world over")
3. (1) over, o'er -- (throughout a period of time; "stay over the weekend")
4. over -- (beyond the top or upper surface or edge; forward from an upright position; "a roof that
hangs over";)
5. all over, over -- (over the entire area; "the wallpaper was covered all over with flowers"; "she
ached all over"; "everything was dusted over with a fine layer of soot")
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