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return kwic search for over out of >500 occurrences
295512 occurrences (No.81 in the rank) during 5 years in the PubMed. [no cache] 500 found

301) The calcium ionophores A231827 and maitotoxin, which are known to induce transamidation, were found to promote apoptosis, whereas cystamine, an active transglutaminase inhibitor, blocked apoptosis due to the over-expression of the active TG isoform.

--- ABSTRACT ---

PMID:24464646 DOI:10.1002/mc.22134

2015 Molecular carcinogenesis

* The 55 kDa tissue transglutaminase cross-linking active isoform TG induces cell death.

- Transamidations are calcium-dependent reactions catalyzed by transglutaminase enzymes. Tissue transglutaminase (TG2 or TGC) is a multifunctional protein with a controversial role in apoptosis. The cross-linking function of transglutaminase enzymes has been shown to play a role in cell death. Human breast cancer cell lines (MCF7 and T47D), which express low endogenous levels of transglutaminase, were transiently transfected with the cross-linking 55 kDa active TG isoform or its precursor the 80 kDa full-length TGC. The increased frequency of apoptosis correlated with the increase in transglutaminase expression and the highest rates of apoptosis were found in cells transfected with the potent TG isoform as compared to the full length TGC. The calcium ionophores A231827 and maitotoxin, which are known to induce transamidation, were found to promote apoptosis, whereas cystamine, an active transglutaminase inhibitor, blocked apoptosis due to the over-expression of the active TG isoform. This is the first time that TG has been used in cellular transfections and the results presented show that TG is a potent inducer of cell death. This finding may help to clarify the conflicting functions of TG in the induction of cell death. The TG-dependent irreversible cross-linking of intracellular proteins, a function previously assigned to TGC, represents an important biochemical event in the induction of the structural changes present in cells during apoptosis.

--- ABSTRACT END ---

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[frequency of next (right) word to over]

(1)145 the	(8)6 their	(15)3 four	(22)2 40
(2)70 time	(9)4 6	(16)3 longer	(23)2 OP
(3)67 a	(10)4 in	(17)3 other	(24)2 another
(4)12 time,	(11)3 1	(18)3 placebo	(25)2 collagen)
(5)9 of	(12)3 12	(19)2 2	(26)2 left
(6)7 and	(13)3 24	(20)2 30	(27)2 long
(7)6 an	(14)3 65	(21)2 4	(28)2 settlement

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--- WordNet output for over --- =>1.超えて, 一面に, 移って, 始めから終わりまで, 終わって, を支配して, の間, しながら, 倒れて, の上に, を覆って, を越えて, の向こう側に, より多く, 2.もう一度, 繰り返して Overview of noun over The noun over has 1 sense (no senses from tagged texts) 1. over -- ((cricket) the division of play during which six balls are bowled at the batsman by one player from the other team from the same end of the pitch) Overview of adj over The adj over has 1 sense (first 1 from tagged texts) 1. (21) complete, concluded, ended, over, all over, terminated -- (having come or been brought to a conclusion; "the harvesting was complete"; "the affair is over, ended, finished"; "the abruptly terminated interview") Overview of adv over The adv over has 5 senses (first 3 from tagged texts) 1. (23) over -- (at or to a point across intervening space etc.; "come over and see us some time"; "over there") 2. (2) over -- (throughout an area; "he is known the world over") 3. (1) over, o'er -- (throughout a period of time; "stay over the weekend") 4. over -- (beyond the top or upper surface or edge; forward from an upright position; "a roof that hangs over";) 5. all over, over -- (over the entire area; "the wallpaper was covered all over with flowers"; "she ached all over"; "everything was dusted over with a fine layer of soot") --- WordNet end ---