ELIZA

return kwic search for patient out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [cache]

113) In this study, we treat BRCA1 mutant cells derived from a patient with triple negative breast cancer and control cells for three weeks with veliparib, a PARPi, to determine if treatment with this drug induces increased levels of mutations and/or an inflammatory response.

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PMID:33285109 DOI:10.1016/j.bcp.2020.114359

2021 Biochemical pharmacology

* Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells.

- Poly-ADP-ribose polymerase (PARP) inhibitors are active against cells and tumors with defects in homology-directed repair as a result of synthetic lethality. PARP inhibitors (PARPi) have been suggested to act by either catalytic inhibition or by PARP localization in chromatin. In this study, we treat BRCA1 mutant cells derived from a patient with triple negative breast cancer and control cells for three weeks with veliparib, a PARPi, to determine if treatment with this drug induces increased levels of mutations and/or an inflammatory response. We show that long-term treatment with PARPi induces an inflammatory response in HCC1937 BRCA1 mutant cells. The levels of chromatin-bound PARP1 in the BRCA1 mutant cells correlate with significant upregulation of inflammatory genes and activation of the cyclic GMP-AMP synthase (cGAS)/signaling effector stimulator of interferon genes (STING pathway). In contrast, an increased mutational load is induced in BRCA1-complemented cells treated with a PARPi. Our results suggest that long-term PARP inhibitor treatment may prime both BRCA1 mutant and wild-type tumors for positive responses to immune checkpoint blockade, but by different underlying mechanisms.

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[frequency of next (right) word to patient]

(1)34 and	(20)4 communication	(39)3 prognosis	(58)2 interactions
(2)28 outcomes	(21)4 experiences	(40)3 satisfaction,	(59)2 monitoring,
(3)26 care	(22)4 knowledge	(41)3 stratification	(60)2 outcomes,
(4)13 safety	(23)4 outcome	(42)3 who	(61)2 outcomes;
(5)12 with	(24)3 access	(43)3 xenograft	(62)2 participation
(6)10 null	(25)3 care,	(44)2 cell	(63)2 perceptions
(7)9 populations	(26)3 characteristics	(45)2 choice	(64)2 perspectives
(8)7 data	(27)3 education	(46)2 classification	(65)2 plasma
(9)7 population	(28)3 group	(47)2 condition	(66)2 population,
(10)7 satisfaction	(29)3 groups	(48)2 costs	(67)2 portals
(11)7 was	(30)3 had	(49)2 demographics,	(68)2 preferences
(12)6 samples	(31)3 is	(50)2 engagement	(69)2 reported
(13)5 characteristics,	(32)3 language	(51)2 expectations	(70)2 samples,
(14)5 cohort	(33)3 medical	(52)2 experience	(71)2 suffering
(15)5 factors	(34)3 monitoring	(53)2 fibroblasts	(72)2 survival,
(16)5 in	(35)3 needs	(54)2 goals	(73)2 that
(17)5 management	(36)3 of	(55)2 groups,	(74)2 to
(18)5 navigation	(37)3 or	(56)2 health	(75)2 tumors
(19)5 survival	(38)3 perspective,	(57)2 information	(76)2 underwent

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--- WordNet output for patient --- =>がまん強い, 忍耐強い, 辛抱強い, 根気よく働く, 患者, 病人, 忠者 Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) Overview of adj patient The adj patient has 1 sense (first 1 from tagged texts) 1. (3) patient -- (enduring trying circumstances with even temper or characterized by such endurance; "a patient smile"; "was patient with the children"; "an exact and patient scientist"; "please be patient") --- WordNet end ---