* Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder.
- Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.
=>がまん強い, 忍耐強い, 辛抱強い, 根気よく働く, 患者, 病人, 忠者
Overview of noun patient
The noun patient has 2 senses (first 1 from tagged texts)
1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown
rapidly")
2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but
is directly involved in or affected by the happening denoted by the verb in the clause)
Overview of adj patient
The adj patient has 1 sense (first 1 from tagged texts)
1. (3) patient -- (enduring trying circumstances with even temper or characterized by such
endurance; "a patient smile"; "was patient with the children"; "an exact and patient scientist";
"please be patient")
--- WordNet end ---