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return kwic search for patient out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [no cache] 500 found

315) However, most patients experienced a relapse in one or more clinical manifestations over time (mean time to relapse 29 ± 21.65 weeks), and only one patient remained completely under control on anakinra monotherapy.

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PMID:24305945 DOI:10.1007/s10067-013-2443-8

2015 Clinical rheumatology

* Anakinra treatment in drug-resistant Behcet's disease: a case series.

- The study objective was to report treatment with an interleukin (IL)-1 receptor antagonist, anakinra, in patients with multiorgan Behcet's disease (BD). Comparison of clinical manifestations, previous treatments, markers of inflammation, concomitant medications, treatment regimen modifications, relapses, and adverse events before and during anakinra administration among patients with BD were evaluated. Nine BD patients (mean age 34.55 ± 16.30 years) refractory to tumor necrosis factor blockers and standardized therapies are reported in our survey. Their mean age at disease onset was 25 ± 13.88 years and their overall disease duration was 9.55 ± 5.33 years. All patients were positive for the HLA-B51 allele. Within 1 or 2 weeks following the initiation of anakinra, eight out of nine patients promptly responded, and most of them were maintained on 100 mg of daily anakinra with low doses of prednisone. However, most patients experienced a relapse in one or more clinical manifestations over time (mean time to relapse 29 ± 21.65 weeks), and only one patient remained completely under control on anakinra monotherapy. Despite a relapse in one or more disease manifestations, treatment was continued in most patients for a mean period of 13.75 ± 6.49 months. No serious adverse events occurred. Eight out of nine refractory BD patients showed a prompt improvement after starting anakinra, supporting the concept that IL-1 plays a pathological role in this disease. Nevertheless, after several months, most patients experienced a relapse. It remains unclear whether increasing the dose of anakinra would have prevented the reoccurrence of disease activity.

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(1)52 with	(17)4 MSCs	(33)3 subsequently	(49)2 motivation
(2)30 was	(18)4 education	(34)2 Education	(50)2 of
(3)20 null	(19)4 presenting	(35)2 achieved	(51)2 outcome
(4)18 and	(20)4 required	(36)2 age	(52)2 pain
(5)15 had	(21)4 safety	(37)2 as	(53)2 population
(6)12 who	(22)4 to	(38)2 assessment	(54)2 population,
(7)11 care	(23)4 were	(39)2 being	(55)2 received
(8)7 is	(24)3 characteristics	(40)2 can	(56)2 remained
(9)7 survival	(25)3 comfort	(41)2 computational	(57)2 remains
(10)7 underwent	(26)3 died	(42)2 data	(58)2 reported
(11)6 developed	(27)3 group	(43)2 days	(59)2 response
(12)6 outcomes	(28)3 information	(44)2 empowerment	(60)2 responses
(13)6 satisfaction	(29)3 life	(45)2 factors,	(61)2 symptoms
(14)5 groups	(30)3 on	(46)2 for	(62)2 the
(15)5 in	(31)3 postoperative	(47)2 immunomigration
(16)5 presented	(32)3 referral	(48)2 including

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--- WordNet output for patient --- =>がまん強い, 忍耐強い, 辛抱強い, 根気よく働く, 患者, 病人, 忠者 Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) Overview of adj patient The adj patient has 1 sense (first 1 from tagged texts) 1. (3) patient -- (enduring trying circumstances with even temper or characterized by such endurance; "a patient smile"; "was patient with the children"; "an exact and patient scientist"; "please be patient") --- WordNet end ---