ELIZA

return kwic search for patients out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [cache]

396) Spectra from the hepatocellular carcinoma (HCC) patients showed consistent differences with respect to those of the control group.

--- ABSTRACT ---

PMID:33294938 DOI:10.1007/s00216-020-03093-7

2021 Analytical and bioanalytical chemistry

* Repeated double cross-validation applied to the PCA-LDA classification of SERS spectra: a case study with serum samples from hepatocellular carcinoma patients.

- Intense label-free surface-enhanced Raman scattering (SERS) spectra of serum samples were rapidly obtained on Ag plasmonic paper substrates upon 785 nm excitation. Spectra from the hepatocellular carcinoma (HCC) patients showed consistent differences with respect to those of the control group. In particular, uric acid was found to be relatively more abundant in patients, while hypoxanthine, ergothioneine, and glutathione were found as relatively more abundant in the control group. A repeated double cross-validation (RDCV) strategy was applied to optimize and validate principal component analysis-linear discriminant analysis (PCA-LDA) models. An analysis of the RDCV results indicated that a PCA-LDA model using up to the first four principal components has a good classification performance (average accuracy was 81%). The analysis also allowed confidence intervals to be calculated for the figures of merit, and the principal components used by the LDA to be interpreted in terms of metabolites, confirming that bands of uric acid, hypoxanthine, ergothioneine, and glutathione were indeed used by the PCA-LDA algorithm to classify the spectra.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to patients]

(1)150 with	(10)6 are	(19)4 the	(28)2 following
(2)63 null	(11)5 diagnosed	(20)3 but	(29)2 from
(3)30 and	(12)5 experience	(21)3 by	(30)2 on
(4)19 were	(13)5 have	(22)3 compared	(31)2 predicted
(5)16 in	(14)4 affected	(23)3 demonstrated	(32)2 presented
(6)11 who	(15)4 at	(24)3 developed	(33)2 received
(7)9 had	(16)4 may	(25)3 during	(34)2 respond
(8)8 to	(17)4 receiving	(26)2 as	(35)2 showed
(9)8 undergoing	(18)4 that	(27)2 can	(36)2 suggesting

add keyword

--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---