* Long-term survival of a child with refractory anaplastic large cell lymphoma following therapy with an antisense oligonucleotide, topotecan, and vinblastine.
- Anaplastic large cell lymphoma includes a subset of highly aggressive tumours and has a relapse rate of 30% at 2 years. Relapsed patients often have poor clinical outcome. The use of antisense oligonucleotides to down-regulate Bcl-2 protein can reverse chemotherapy resistance. The authors describe an 11-year-old boy with recurrent anaplastic large cell lymphoma who had received double high-dose chemotherapy followed by autologous haematopoietic stem-cell transplantation, had refractory disease and then had achieved long-term remission with the use of an antisense oligonucleotides in combination with vinblastine and topotecan.
Overview of noun patient
The noun patient has 2 senses (first 1 from tagged texts)
1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown
rapidly")
2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but
is directly involved in or affected by the happening denoted by the verb in the clause)
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