ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for patients with out of >500 occurrences
404916 occurrences (No.41 in the rank) during 5 years in the PubMed. [cache]
161) Because sympathetic activation prevents blood pressure (BP) from falling in healthy subjects exposed to heat, we hypothesized that passive heat had a BP-lowering effect in patients with autonomic failure and could be used to treat their supine hypertension.
--- ABSTRACT ---
PMID:33739123 DOI:10.1161/JAHA.120.018979
2021 Journal of the American Heart Association
* Local Passive Heat for the Treatment of Hypertension in Autonomic Failure.
- Background Supine hypertension affects a majority of patients with autonomic failure; it is associated with end-organ damage and can worsen daytime orthostatic hypotension by inducing pressure diuresis and volume loss during the night. Because sympathetic activation prevents blood pressure (BP) from falling in healthy subjects exposed to heat, we hypothesized that passive heat had a BP-lowering effect in patients with autonomic failure and could be used to treat their supine hypertension. Methods and Results In Protocol 1 (n=22), the acute effects of local heat (40-42°C applied with a heating pad placed over the abdomen for 2 hours) versus sham control were assessed in a randomized crossover fashion. Heat acutely decreased systolic BP by -19±4 mm Hg (versus 3±4 with sham, P<0.001) owing to decreases in stroke volume (-18±5% versus -4±4%, P=0.013 ) and cardiac output (-15±5% versus -2±4%, P=0.013). In Protocol 2 (proof-of-concept overnight study; n=12), we compared the effects of local heat (38°C applied with a water-perfused heating pad placed under the torso from 10 pm to 6 am) versus placebo pill. Heat decreased nighttime systolic BP (maximal change -28±6 versus -2±6 mm Hg, P<0.001). BP returned to baseline by 8 am. The nocturnal systolic BP decrease correlated with a decrease in urinary volume (r=0.57, P=0.072) and an improvement in the morning upright systolic BP (r=-0.76, P=0.007). Conclusions Local heat therapy effectively lowered overnight BP in patients with autonomic failure and supine hypertension and offers a novel approach to treat this condition. Future studies are needed to assess the long-term safety and efficacy in improving nighttime fluid loss and daytime orthostatic hypotension. Registration URL: https://www.clinicaltrials.gov; Unique identifiers: NCT02417415 and NCT03042988.
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(1)14 a (26)3 PAH (51)2 IgAn (76)2 neurological
(2)14 severe (27)3 PTB (52)2 MIS-C (77)2 no
(3)12 COVID-19 (28)3 SB (53)2 MS, (78)2 or
(4)10 cancer (29)3 and (54)2 PH, (79)2 pancreatic
(5)10 chronic (30)3 autonomic (55)2 TSC (80)2 pre-existing
(6)8 diabetes (31)3 clinical (56)2 UWS (81)2 prolonged
(7)7 acute (32)3 dysphagia (57)2 accuracies (82)2 psoriasis
(8)6 relapsed (33)3 epilepsy (58)2 ankylosing (83)2 pulmonary
(9)5 AN (34)3 idiopathic (59)2 any (84)2 resected
(10)5 MDD (35)3 inflammatory (60)2 cerebellar (85)2 respiratory
(11)5 T2DM (36)3 newly (61)2 community-based (86)2 rheumatoid
(12)5 advanced (37)3 recurrent (62)2 comorbidities (87)2 schizophrenia
(13)5 lipoedema (38)3 uncontrolled (63)2 drug-resistant (88)2 shared
(14)4 AD (39)2 16p11.2 (64)2 heart (89)2 special
(15)4 IBD (40)2 ALL (65)2 hemorrhagic (90)2 spondyloarthritis
(16)4 breast (41)2 ALS (66)2 high (91)2 stage
(17)4 chorea (42)2 AML (67)2 high-risk (92)2 suspected
(18)4 critical (43)2 ASD (68)2 known (93)2 symptomatic
(19)4 low (44)2 BM (69)2 locally (94)2 the
(20)3 ARDS (45)2 CHB (70)2 lung (95)2 these
(21)3 CKD (46)2 COVID-19, (71)2 mIDH1 (96)2 treatment-resistant
(22)3 CLL (47)2 CRC (72)2 major (97)2 tuberculosis
(23)3 HGSOC (48)2 CVDRF (73)2 metastatic
(24)3 ILD (49)2 HIV (74)2 mild
(25)3 MD (50)2 IIM (75)2 neurologic

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--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---