ELIZA

return kwic search for patients with out of >500 occurrences
404916 occurrences (No.41 in the rank) during 5 years in the PubMed. [cache]

2) Survival time and chemotherapy responses between patients were compared with the TT genotype and patients with a genotype containing a G allele (GT, GG).

--- ABSTRACT ---

PMID:34429773 DOI:10.3892/ol.2021.12994

2021 Oncology letters

* A nuclear polymorphism at the 8q24 region is associated with improved survival time and chemo-response in high-grade serous ovarian cancer.

- The 8q24 chromosomal region is strongly associated with an increased risk of ovarian cancer. One single nucleotide polymorphism that is associated with ovarian cancer in this region is rs6983267, located within the long non-coding RNA colon cancer associated transcript 2 (CCAT2). The aim of the present study was to assess the association between rs6983267 and clinical outcomes in patients with high-grade serous ovarian cancer (HGSOC). The present retrospective genetic association study utilized Sanger sequencing to determine the genotype at the rs6983267 locus (GG, GT, TT) in 98 patients with HGSOC. Survival time and chemotherapy responses between patients were compared with the TT genotype and patients with a genotype containing a G allele (GT, GG). Survival analyses were performed using Cox proportional hazard ratio analysis. Association with chemo-response was performed using a logistic regression. The results revealed that patients with HGSOC and the TT genotype at the rs6983267 locus had improved survival time compared with patients with genotypes containing a G allele [hazard ratio=0.59; 95% confidence interval (CI), 0.36-0.97; P=0.039] and were significantly associated with International Federation of Gynecology and Obstetrics stage [odds ratio (OR)=5.34; 95% CI, 1.50-22.62; P=0.014] and positive chemo-response (OR=4.51; 95% CI, 1.40-18.00; P=0.018). In summary, patients with HGSOC and the TT genotype at the rs6983267 locus had improved survival time compared with those with a G allele, despite being associated with more advanced disease; this was possibly due to an improved response to chemotherapy.

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(1)14 a	(26)3 PAH	(51)2 IgAn	(76)2 neurological
(2)14 severe	(27)3 PTB	(52)2 MIS-C	(77)2 no
(3)12 COVID-19	(28)3 SB	(53)2 MS,	(78)2 or
(4)10 cancer	(29)3 and	(54)2 PH,	(79)2 pancreatic
(5)10 chronic	(30)3 autonomic	(55)2 TSC	(80)2 pre-existing
(6)8 diabetes	(31)3 clinical	(56)2 UWS	(81)2 prolonged
(7)7 acute	(32)3 dysphagia	(57)2 accuracies	(82)2 psoriasis
(8)6 relapsed	(33)3 epilepsy	(58)2 ankylosing	(83)2 pulmonary
(9)5 AN	(34)3 idiopathic	(59)2 any	(84)2 resected
(10)5 MDD	(35)3 inflammatory	(60)2 cerebellar	(85)2 respiratory
(11)5 T2DM	(36)3 newly	(61)2 community-based	(86)2 rheumatoid
(12)5 advanced	(37)3 recurrent	(62)2 comorbidities	(87)2 schizophrenia
(13)5 lipoedema	(38)3 uncontrolled	(63)2 drug-resistant	(88)2 shared
(14)4 AD	(39)2 16p11.2	(64)2 heart	(89)2 special
(15)4 IBD	(40)2 ALL	(65)2 hemorrhagic	(90)2 spondyloarthritis
(16)4 breast	(41)2 ALS	(66)2 high	(91)2 stage
(17)4 chorea	(42)2 AML	(67)2 high-risk	(92)2 suspected
(18)4 critical	(43)2 ASD	(68)2 known	(93)2 symptomatic
(19)4 low	(44)2 BM	(69)2 locally	(94)2 the
(20)3 ARDS	(45)2 CHB	(70)2 lung	(95)2 these
(21)3 CKD	(46)2 COVID-19,	(71)2 mIDH1	(96)2 treatment-resistant
(22)3 CLL	(47)2 CRC	(72)2 major	(97)2 tuberculosis
(23)3 HGSOC	(48)2 CVDRF	(73)2 metastatic
(24)3 ILD	(49)2 HIV	(74)2 mild
(25)3 MD	(50)2 IIM	(75)2 neurologic

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--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---