ELIZA

return kwic search for performed out of >500 occurrences
272110 occurrences (No.94 in the rank) during 5 years in the PubMed. [cache]

264) Electrophysiological recordings were then performed on juvenile offspring prior to weaning.

--- ABSTRACT ---

PMID:34564357 DOI:10.3390/toxics9090206

2021 Toxics

* Early Low-Level Arsenic Exposure Impacts Post-Synaptic Hippocampal Function in Juvenile Mice.

- Arsenic is a well-established carcinogen known to increase mortality, but its effects on the central nervous system are less well understood. Epidemiological studies suggest that early life exposure is associated with learning deficits and behavioral changes. Studies in arsenic-exposed rodents have begun to shed light on potential mechanistic underpinnings, including changes in synaptic transmission and plasticity. However, previous studies relied on extended exposure into adulthood, and little is known about the effect of arsenic exposure in early development. Here, we studied the effects of early developmental arsenic exposure in juvenile mice on synaptic transmission and plasticity in the hippocampus. C57BL/6J females were exposed to arsenic (0, 50 ppb, 36 ppm) via drinking water two weeks prior to mating, with continued exposure throughout gestation and parturition. Electrophysiological recordings were then performed on juvenile offspring prior to weaning. In this paradigm, the offspring are exposed to arsenic indirectly, via the mother. We found that high (36 ppm) and relatively low (50 ppb) arsenic exposure both decreased basal synaptic transmission. A compensatory increase in pre-synaptic vesicular release was only observed in the high-exposure group. These results suggest that indirect, ecologically relevant arsenic exposure in early development impacts hippocampal synaptic transmission and plasticity that could underlie learning deficits reported in epidemiological studies.

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[frequency of next (right) word to performed]

(1)59 a	(10)11 and	(19)3 according	(28)2 multilevel
(2)57 to	(11)7 an	(20)3 single	(29)2 qualitative
(3)53 in	(12)7 for	(21)2 (N	(30)2 searching
(4)40 null	(13)5 after	(22)2 at	(31)2 significantly
(5)40 using	(14)5 independently	(23)2 based	(32)2 single-cell
(6)36 on	(15)5 through	(24)2 both	(33)2 this
(7)26 by	(16)4 better	(25)2 during	(34)2 three
(8)18 with	(17)4 following	(26)2 mass	(35)2 two
(9)15 the	(18)4 well	(27)2 maximal

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--- WordNet output for performed --- Overview of verb perform The verb perform has 4 senses (first 4 from tagged texts) 1. (25) perform, execute, do -- (carry out or perform an action; "John did the painting, the weeding, and he cleaned out the gutters"; "the skater executed a triple pirouette"; "she did a little dance") 2. (19) perform -- (perform a function; "Who will perform the wedding?") 3. (19) perform -- (give a performance (of something); "Horowitz is performing at Carnegie Hall tonight"; "We performed a popular Gilbert and Sullivan opera") 4. (2) do, perform -- (get (something) done; "I did my job") --- WordNet end ---