ELIZA

return kwic search for performed out of >500 occurrences
272110 occurrences (No.94 in the rank) during 5 years in the PubMed. [cache]

62) A parametric analysis of both increasing membrane stiffness (thereby modelling membrane peroxidation with age) and decreasing density of cytoskeletal elements (thereby modelling reduced actin density with age) was performed.

--- ABSTRACT ---

PMID:23947334 DOI:10.1080/10255842.2013.811234

2015 Computer methods in biomechanics and biomedical engineering

* Effect of membrane stiffness and cytoskeletal element density on mechanical stimuli within cells: an analysis of the consequences of ageing in cells.

- A finite element model of a single cell was created and used to compute the biophysical stimuli generated within a cell under mechanical loading. Major cellular components were incorporated in the model: the membrane, cytoplasm, nucleus, microtubules, actin filaments, intermediate filaments, nuclear lamina and chromatin. The model used multiple sets of tensegrity structures. Viscoelastic properties were assigned to the continuum components. To corroborate the model, a simulation of atomic force microscopy indentation was performed and results showed a force/indentation simulation with the range of experimental results. A parametric analysis of both increasing membrane stiffness (thereby modelling membrane peroxidation with age) and decreasing density of cytoskeletal elements (thereby modelling reduced actin density with age) was performed. Comparing normal and aged cells under indentation predicts that aged cells have a lower membrane area subjected to high strain as compared with young cells, but the difference, surprisingly, is very small and may not be measurable experimentally. Ageing is predicted to have a more significant effect on strain deep in the nucleus. These results show that computation of biophysical stimuli within cells are achievable with single-cell computational models; correspondence between computed and measured force/displacement behaviours provides a high-level validation of the model. Regarding the effect of ageing, the models suggest only small, although possibly physiologically significant, differences in internal biophysical stimuli between normal and aged cells.

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[frequency of next (right) word to performed]

(1)60 in	(10)15 for	(19)3 based	(28)2 equally
(2)58 null	(11)13 at	(20)3 of	(29)2 normally
(3)45 to	(12)6 as	(21)3 this	(30)2 procedures
(4)35 using	(13)5 the	(22)2 3	(31)2 successfully
(5)33 on	(14)5 under	(23)2 6	(32)2 three
(6)30 with	(15)5 via	(24)2 better	(33)2 through
(7)23 by	(16)4 an	(25)2 both	(34)2 twice
(8)22 a	(17)4 before	(26)2 but
(9)16 and	(18)3 after	(27)2 daily

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--- WordNet output for performed --- Overview of verb perform The verb perform has 4 senses (first 4 from tagged texts) 1. (25) perform, execute, do -- (carry out or perform an action; "John did the painting, the weeding, and he cleaned out the gutters"; "the skater executed a triple pirouette"; "she did a little dance") 2. (19) perform -- (perform a function; "Who will perform the wedding?") 3. (19) perform -- (give a performance (of something); "Horowitz is performing at Carnegie Hall tonight"; "We performed a popular Gilbert and Sullivan opera") 4. (2) do, perform -- (get (something) done; "I did my job") --- WordNet end ---