* Toxicity associated with repeated administration of artemether-lumefantrine in rats.
- Chemotherapy remains an important approach in the fight against malaria. Artemether-lumefantrine combination is widely in use due to its effectiveness against Plasmodium falciparum. Misuse in the form of multiple repeated doses of this anti-malaria drug is rampant in Nigeria. This study was designed to assess the hepatotoxic and clastogenic potential of extreme misuse of artemether-lumefantrine in rats. Graded doses of artemether-lumefantrine (1-5 mg/kg body weight) were administered by oral gavage for 6 weeks, twice daily, for 3 consecutive days per week. Artemether-lumefantrine, at all doses, did not have significant effects on the body and relative liver weight of treated group compared to the negative control group. The mean γ-glutamyltransferase, alanine, and aspartate aminotransaminase activity in groups of artemether-lumefantrine treated rats were significantly higher (p < 0.05) than that of the negative control group indicating that repeated administration of artemether-lumefantrine may be hepatotoxic. Findings from histological analyses of liver cross-section support the enzyme pattern of hepatoxicity. In addition, the drug, at all experimental doses, significantly induced (p < 0.05) formation of micronucleated polychromatic erythrocytes in the bone marrow cells of the treated rats compared with the negative control indicating clastogenic potential of the drug when misused.
=>可能性のある, 可能な, 潜在力のある, 位置の, 電位の, 潜在的な, ポテンシャル, 可能性, 電位
Overview of noun potential
The noun potential has 2 senses (first 1 from tagged texts)
1. (10) potential, potentiality, potency -- (the inherent capacity for coming into being)
2. electric potential, potential, potential difference, potential drop, voltage -- (the difference
in electrical charge between two points in a circuit expressed in volts)
Overview of adj potential
The adj potential has 2 senses (first 2 from tagged texts)
1. (7) potential, possible -- (existing in possibility; "a potential problem"; "possible uses of
nuclear power")
2. (6) likely, potential -- (expected to become or be; in prospect; "potential clients")
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