207) Estradiol in vivo in obese rats resulted in a significant increase in protein kinase B (Akt) activation (P < .05) and decrease in heart mass (P < .05), ratio of the heart mass/body mass (P < .05), transverse diameters of cardiomyocytes (P < .001), concentration of serum high-sensitivity C-reactive protein (P < .001), and total cholesterol (P < .01) compared with obese nontreated rats. |
PMID:24327768 DOI:10.1177/0003319713514477 |
2015 Angiology |
* Estradiol in vivo induces changes in cardiomyocytes size in obese rats. |
- We studied the in vivo effects of estradiol on size and biochemical parameters of cardiomyocytes in pathophysiological conditions such as obesity and insulin resistance. Male Wistar rats were normally fed (controls, n = 7) or fed with high-fat diet (obese, n = 14). Half of the obese rats (obese + estradiol, n = 7) were treated with a single dose of estradiol (40 μg/kg, intraperitoneally) and 24 hours after treatment all the rats were killed. Estradiol in vivo in obese rats resulted in a significant increase in protein kinase B (Akt) activation (P < .05) and decrease in heart mass (P < .05), ratio of the heart mass/body mass (P < .05), transverse diameters of cardiomyocytes (P < .001), concentration of serum high-sensitivity C-reactive protein (P < .001), and total cholesterol (P < .01) compared with obese nontreated rats. Our results suggest that estradiol in obese/IR rats affects the size of cardiomyocytes and its actions lead in vivo to a reduction in obesity-induced cardiac hypertrophy, via Akt. |
(1)76 genes, | (11)8 was | (21)3 has | (31)2 for |
(2)45 genes | (12)7 level | (22)3 is | (32)2 initiation |
(3)24 and | (13)6 carbonyl | (23)3 of | (33)2 level, |
(4)23 levels | (14)6 coding | (24)3 oxidation, | (34)2 production |
(5)18 expression | (15)5 C | (25)3 stability | (35)2 sequences |
(6)12 *null* | (16)5 gene | (26)3 thiol | (36)2 solutions |
(7)12 kinase | (17)5 isolate | (27)2 acid | (37)2 structures |
(8)9 1 | (18)5 kinases | (28)2 content | (38)2 that |
(9)9 in | (19)4 levels, | (29)2 contents | |
(10)8 2 | (20)3 expression, | (30)2 families |
add keyword