ELIZA

return kwic search for protein out of >500 occurrences
536761 occurrences (No.22 in the rank) during 5 years in the PubMed. [cache]

93) In the current investigation, we compare the effects of short-term (8 weeks) Rap and Rap + Met treatments on bulk and individual protein synthesis in two key metabolic organs (the liver and skeletal muscle) of young genetically heterogeneous mice using deuterium oxide.

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PMID:32761290 DOI:10.1007/s11357-020-00243-8

2021 GeroScience

* Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin.

- Loss of protein homeostasis is a hallmark of the aging process. We and others have previously shown that maintenance of proteostasis is a shared characteristic of slowed-aging models. Rapamycin (Rap) exerts sex-specific effects on murine lifespan, but the combination of Rap with the anti-hyperglycemic drug metformin (Rap + Met) equally increases male and female mouse median lifespan. In the current investigation, we compare the effects of short-term (8 weeks) Rap and Rap + Met treatments on bulk and individual protein synthesis in two key metabolic organs (the liver and skeletal muscle) of young genetically heterogeneous mice using deuterium oxide. We report for the first time distinct effects of Rap and Rap + Met treatments on bulk and individual protein synthesis in young mice. Although there were decreases in protein synthesis as assessed by bulk measurements, individual protein synthesis analyses demonstrate there were nearly as many proteins that increased synthesis as decreased synthesis rates. While we observed the established sex- and tissue-specific effects of Rap on protein synthesis, adding Met yielded more uniform effects between tissue and sex. These data offer mechanistic insight as to how Rap + Met may extend lifespan in both sexes while Rap does not.

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[frequency of next (right) word to protein]

(1)24 expression	(18)4 binding	(35)3 interaction	(52)2 folding
(2)20 and	(19)4 components	(36)3 involved	(53)2 gene
(3)18 null	(20)4 from	(37)3 modifications	(54)2 kinases
(4)15 kinase	(21)4 function	(38)3 with	(55)2 kinases,
(5)11 levels	(22)4 import	(39)2 (BCRP),	(56)2 level
(6)9 synthesis	(23)4 interactions	(40)2 (CRP)	(57)2 levels,
(7)8 1	(24)4 of	(41)2 adducts	(58)2 mass
(8)8 abundance	(25)4 or	(42)2 aggregation	(59)2 may
(9)8 that	(26)4 to	(43)2 approach	(60)2 networks
(10)7 receptors	(27)3 (BCRP)	(44)2 as	(61)2 per
(11)6 receptor	(28)3 9	(45)2 binding,	(62)2 quantification
(12)5 3	(29)3 a	(46)2 bound	(63)2 response
(13)5 in	(30)3 activation	(47)2 coupling	(64)2 restriction
(14)5 is	(31)3 biomarkers	(48)2 diet	(65)2 structure
(15)5 pool	(32)3 coupled	(49)2 during	(66)2 synthesis,
(16)5 was	(33)3 degradation	(50)2 expression,	(67)2 targets
(17)4 2	(34)3 genes	(51)2 family

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--- WordNet output for protein --- =>タンパク質, 蛋白質, たん白質 Overview of noun protein The noun protein has 1 sense (first 1 from tagged texts) 1. (23) protein -- (any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein") --- WordNet end ---