ELIZA

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325270 occurrences (No.61 in the rank) during 5 years in the PubMed. [cache]

221) The availability of large biobanks with deeply phenotyped subjects such as the UK Biobank enables the investigation of sex-specific genetic associations that may provide new insights into COPD risk factors.

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PMID:35308900 DOI:10.3389/fphys.2022.825819

2021 AMIA ... Annual Symposium proceedings. AMIA Symposium

* Gene-Based Analysis Reveals Sex-Specific Genetic Risk Factors of COPD.

- Sex-specific differences have been noted among people with chronic obstructive pulmonary disease (COPD), but whether these differences are attributable to genetic variation is poorly understood. The availability of large biobanks with deeply phenotyped subjects such as the UK Biobank enables the investigation of sex-specific genetic associations that may provide new insights into COPD risk factors. We performed sex-stratified genome-wide association studies (GWAS) of COPD (male: 12,958 cases and 95,631 controls; female: 11,311 cases and 123,714 controls) and found that while most associations were shared between sexes, several regions had sex-specific contributions, including respiratory viral infection-related loci in/near C5orf56 and PELI1. Using the newly developed R package 'snpsettest', we performed gene-based association tests and identified gene-level sex-specific associations, including C5orf56 on 5q31.1, CFDP1/TMEM170A/CHST6 on 16q23.1 and ASTN2/TRIM32 on 9q33.1. Our results identified promising genes to pursue in functional studies to better understand sexual dimorphism in COPD.

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[frequency of next (right) word to provide]

(1)125 a	(12)7 insight	(23)3 sufficient	(34)2 patients
(2)63 an	(13)7 more	(24)3 support	(35)2 protection
(3)15 evidence	(14)6 guidance	(25)2 adequate	(36)2 readers
(4)13 the	(15)6 information	(26)2 care	(37)2 reasonable
(5)12 new	(16)6 some	(27)2 critical	(38)2 reliable
(6)11 recommendations	(17)5 novel	(28)2 detailed	(39)2 robust
(7)9 insights	(18)4 better	(29)2 direct	(40)2 strong
(8)9 valuable	(19)4 opportunities	(30)2 greater	(41)2 suggestions
(9)7 additional	(20)4 useful	(31)2 hypotheses	(42)2 treatment
(10)7 further	(21)3 practical	(32)2 key
(11)7 important	(22)3 researchers	(33)2 mechanistic

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--- WordNet output for provide --- =>供給する, 与える, 規定する, 条件とする, 準備する, 用意する, 扶養する, 援助する Overview of verb provide The verb provide has 7 senses (first 4 from tagged texts) 1. (270) supply, provide, render, furnish -- (give something useful or necessary to; "We provided the room with an electrical heater") 2. (25) provide, supply, ply, cater -- (give what is desired or needed, especially support, food or sustenance; "The hostess provided lunch for all the guests") 3. (14) provide -- (determine (what is to happen in certain contingencies), especially by including a proviso condition or stipulation; "The will provides that each child should receive half of the money"; "The Constitution provides for the right to free speech") 4. (2) put up, provide, offer -- (mount or put up; "put up a good fight"; "offer resistance") 5. leave, allow for, allow, provide -- (make a possibility or provide opportunity for; permit to be attainable or cause to remain; "This leaves no room for improvement"; "The evidence allows only one conclusion"; "allow for mistakes"; "leave lots of time for the trip"; "This procedure provides for lots of leeway") 6. provide, bring home the bacon -- (supply means of subsistence; earn a living; "He provides for his large family by working three jobs"; "Women nowadays not only take care of the household but also bring home the bacon") 7. provide -- (take measures in preparation for; "provide for the proper care of the passengers on the cruise ship") --- WordNet end ---