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325270 occurrences (No.61 in the rank) during 5 years in the PubMed. [no cache] 500 found

259) These findings provide additional evidence that E.

--- ABSTRACT ---

PMID:39778647 DOI:10.1016/j.fct.2025.115241

2025 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

* Impact of Endocrine Disruptors on Key Events of Hepatic Steatosis in HepG2 Cells.

- Endocrine-disrupting compounds (EDCs) may contribute to the rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD). We investigated the potential of 10 environmentally relevant EDCs to affect key events of hepatic steatosis in HepG2 human hepatoma cells. Increased lipid droplet formation, a key marker of steatosis, was induced by PFOA, bisphenol F, DDE, butylparaben, and DEHP, within the non-cytotoxic concentration range of 1 nM-25 μM. Cadmium also induced this effect, but at concentrations impairing cell viability (>1 μM). At non-cytotoxic concentrations, these compounds, along with bisphenol A, dysregulated major genes controlling lipid homeostasis. Cadmium, PFOA, DDE, and DEHP significantly upregulated the DGAT1 gene involved in triglyceride synthesis, while butylparaben increased the expression of the FAT/CD36 gene responsible for fatty acid uptake. Bisphenol A downregulated the CPT1A gene involved in fatty acid oxidation. No significant effects on lipid droplet accumulation or lipid metabolism-related genes were observed for PFOS, bisphenol S, and dibutyl phthalate. Among the tested EDCs, lipid accumulation positively correlated with the expression of SREBF1, DGAT1, and CPT1A. These findings provide additional evidence that E.Cs can affect MASLD and highlight the utility of in vitro methods in the screening of EDCs with hazardous steatogenic and metabolism-disrupting properties.

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[frequency of next (right) word to provide]

(1)125 a	(12)7 insight	(23)3 sufficient	(34)2 patients
(2)63 an	(13)7 more	(24)3 support	(35)2 protection
(3)15 evidence	(14)6 guidance	(25)2 adequate	(36)2 readers
(4)13 the	(15)6 information	(26)2 care	(37)2 reasonable
(5)12 new	(16)6 some	(27)2 critical	(38)2 reliable
(6)11 recommendations	(17)5 novel	(28)2 detailed	(39)2 robust
(7)9 insights	(18)4 better	(29)2 direct	(40)2 strong
(8)9 valuable	(19)4 opportunities	(30)2 greater	(41)2 suggestions
(9)7 additional	(20)4 useful	(31)2 hypotheses	(42)2 treatment
(10)7 further	(21)3 practical	(32)2 key
(11)7 important	(22)3 researchers	(33)2 mechanistic

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--- WordNet output for provide --- =>供給する, 与える, 規定する, 条件とする, 準備する, 用意する, 扶養する, 援助する Overview of verb provide The verb provide has 7 senses (first 4 from tagged texts) 1. (270) supply, provide, render, furnish -- (give something useful or necessary to; "We provided the room with an electrical heater") 2. (25) provide, supply, ply, cater -- (give what is desired or needed, especially support, food or sustenance; "The hostess provided lunch for all the guests") 3. (14) provide -- (determine (what is to happen in certain contingencies), especially by including a proviso condition or stipulation; "The will provides that each child should receive half of the money"; "The Constitution provides for the right to free speech") 4. (2) put up, provide, offer -- (mount or put up; "put up a good fight"; "offer resistance") 5. leave, allow for, allow, provide -- (make a possibility or provide opportunity for; permit to be attainable or cause to remain; "This leaves no room for improvement"; "The evidence allows only one conclusion"; "allow for mistakes"; "leave lots of time for the trip"; "This procedure provides for lots of leeway") 6. provide, bring home the bacon -- (supply means of subsistence; earn a living; "He provides for his large family by working three jobs"; "Women nowadays not only take care of the household but also bring home the bacon") 7. provide -- (take measures in preparation for; "provide for the proper care of the passengers on the cruise ship") --- WordNet end ---