* LncRNAs: new players in gliomas, with special emphasis on the interaction of lncRNAs With EZH2.
- Gliomas are the most common primary malignancy in the brain, accounting for 50-60%. Despite all the efforts of cytoreductive surgery in combination with intense chemoradiotherapy, glioma remains an incurable disease. Recent studies have shown that long noncoding RNAs (lncRNAs) are involved in the pathology of gliomas. LncRNAs are involved in many cellular processes, such as angiogenesis, invasion, cell proliferation, and apoptosis. In this review we focus on the dysregulation of lncRNAs in gliomas. We also address that epigenetic modification such as DNA methylation and microRNAs interact with lncRNAs in gliomas. In addition, the interaction of lncRNAs with signaling pathways in gliomas is discussed systematically, with particular emphasis on the interaction of lncRNAs with EZH2. Such approaches provide valuable insights into the potential future applications of lncRNAs in the treatment of gliomas.
=>供給する, 与える, 規定する, 条件とする, 準備する, 用意する, 扶養する, 援助する
Overview of verb provide
The verb provide has 7 senses (first 4 from tagged texts)
1. (270) supply, provide, render, furnish -- (give something useful or necessary to; "We provided
the room with an electrical heater")
2. (25) provide, supply, ply, cater -- (give what is desired or needed, especially support, food or
sustenance; "The hostess provided lunch for all the guests")
3. (14) provide -- (determine (what is to happen in certain contingencies), especially by including
a proviso condition or stipulation; "The will provides that each child should receive half of the
money"; "The Constitution provides for the right to free speech")
4. (2) put up, provide, offer -- (mount or put up; "put up a good fight"; "offer resistance")
5. leave, allow for, allow, provide -- (make a possibility or provide opportunity for; permit to be
attainable or cause to remain; "This leaves no room for improvement"; "The evidence allows only one
conclusion"; "allow for mistakes"; "leave lots of time for the trip"; "This procedure provides for
lots of leeway")
6. provide, bring home the bacon -- (supply means of subsistence; earn a living; "He provides for
his large family by working three jobs"; "Women nowadays not only take care of the household but
also bring home the bacon")
7. provide -- (take measures in preparation for; "provide for the proper care of the passengers on
the cruise ship")
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