ELIZA

return kwic search for provide out of >500 occurrences
325270 occurrences (No.61 in the rank) during 5 years in the PubMed. [cache]

386) Enhanced levels of SIRT6 expression or activity provide avenues for rejuvenation strategies.

--- ABSTRACT ---

PMID:34281779 DOI:10.1016/j.tcb.2021.06.009

2021 Trends in cell biology

* Sirtuin 6: linking longevity with genome and epigenome stability.

- Sirtuin 6 (SIRT6) has been in the spotlight of aging research because progeroid phenotypes are associated with SIRT6 deficiency. SIRT6 has multiple molecular functions, including DNA repair and heterochromatin regulation, which position SIRT6 as a hub that regulates genome and epigenome stability. Genomic instability caused by persistent DNA damage and accumulating mutations, together with alterations in the epigenetic landscape and derepression of repetitive genetic elements, have emerged as mechanisms driving organismal aging. Enhanced levels of SIRT6 expression or activity provide avenues for rejuvenation strategies. This review focuses on the role of SIRT6 in the maintenance of genome and epigenome stability and its link to longevity. We propose a model where SIRT6 together with lamins control aging and rejuvenation by maintaining epigenetic silencing of repetitive elements.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to provide]

(1)125 a	(12)7 insight	(23)3 sufficient	(34)2 patients
(2)63 an	(13)7 more	(24)3 support	(35)2 protection
(3)15 evidence	(14)6 guidance	(25)2 adequate	(36)2 readers
(4)13 the	(15)6 information	(26)2 care	(37)2 reasonable
(5)12 new	(16)6 some	(27)2 critical	(38)2 reliable
(6)11 recommendations	(17)5 novel	(28)2 detailed	(39)2 robust
(7)9 insights	(18)4 better	(29)2 direct	(40)2 strong
(8)9 valuable	(19)4 opportunities	(30)2 greater	(41)2 suggestions
(9)7 additional	(20)4 useful	(31)2 hypotheses	(42)2 treatment
(10)7 further	(21)3 practical	(32)2 key
(11)7 important	(22)3 researchers	(33)2 mechanistic

add keyword

--- WordNet output for provide --- =>供給する, 与える, 規定する, 条件とする, 準備する, 用意する, 扶養する, 援助する Overview of verb provide The verb provide has 7 senses (first 4 from tagged texts) 1. (270) supply, provide, render, furnish -- (give something useful or necessary to; "We provided the room with an electrical heater") 2. (25) provide, supply, ply, cater -- (give what is desired or needed, especially support, food or sustenance; "The hostess provided lunch for all the guests") 3. (14) provide -- (determine (what is to happen in certain contingencies), especially by including a proviso condition or stipulation; "The will provides that each child should receive half of the money"; "The Constitution provides for the right to free speech") 4. (2) put up, provide, offer -- (mount or put up; "put up a good fight"; "offer resistance") 5. leave, allow for, allow, provide -- (make a possibility or provide opportunity for; permit to be attainable or cause to remain; "This leaves no room for improvement"; "The evidence allows only one conclusion"; "allow for mistakes"; "leave lots of time for the trip"; "This procedure provides for lots of leeway") 6. provide, bring home the bacon -- (supply means of subsistence; earn a living; "He provides for his large family by working three jobs"; "Women nowadays not only take care of the household but also bring home the bacon") 7. provide -- (take measures in preparation for; "provide for the proper care of the passengers on the cruise ship") --- WordNet end ---