ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for reduced out of >500 occurrences
290904 occurrences (No.84 in the rank) during 5 years in the PubMed. [cache]
259) MRI volumetric analysis of tumor-bearing rats indicated significantly reduced tumor volume with cisplatin-loaded targeted-nanogel treatment compared to other formulations.
--- ABSTRACT ---
PMID:24437962 DOI:10.3109/10717544.2013.876460
2015 Drug delivery
* Treatment of glioma by cisplatin-loaded nanogels conjugated with monoclonal antibodies against Cx43 and BSAT1.
- Targeted drug delivery for brain tumor treatment is one of the important objectives in nanomedicine. Human glioblastoma is the most frequent and aggressive type of brain tumors. The preferential expression of membrane protein connexin 43 (Cx43) and brain-specific anion transporter (BSAT1) in the tumor and peritumoral area is a key component for targeted drug delivery. The purpose of this study was to design cisplatin-loaded nanogels conjugated with monoclonal antibodies to Cx43 and BSAT1 for treatment of intracranial gliomas 101/8. MRI volumetric analysis of tumor-bearing rats indicated significantly reduced tumor volume with cisplatin-loaded targeted-nanogel treatment compared to other formulations. The median survival of rats treated with targeted nanogels conjugated with specific mAbs against extracellular loops of Cx43 and BSAT1 were 27 and 26.6 days higher than that in control group, respectively. For the first time we demonstrated the efficiency of mAb-targeted cisplatin-loaded nanogels in the experimental model of glioma 101/8. This approach could facilitate the development of new drug delivery systems for the treatment of gliomas.
--- ABSTRACT END ---
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(1)66 the (12)4 activity (24)2 among (35)2 interhemispheric
(2)30 in (13)4 both (25)2 availability (36)2 it
(3)23 by (14)4 cell (26)2 blood (37)2 likelihood
(4)13 *null* (16)3 ability (27)2 but (38)2 number
(5)13 to (17)3 after (28)2 compared (39)2 rates
(6)10 glutathione (18)3 binding (29)2 effortful (40)2 stem
(7)8 and (19)3 or (30)2 ejection (41)2 total
(8)8 expression (20)3 risk (31)2 following (42)2 tumor
(9)5 levels (21)3 sensitivity (32)2 from (43)2 which
(10)5 significantly (22)2 (P (33)2 glutathione,
(11)4 PGE2 (23)2 BRCA-1 (34)2 hippocampal

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--- WordNet output for reduced --- =>貧しい暮らし, 落ちぶれた生活 Overview of verb reduce The verb reduce has 20 senses (first 11 from tagged texts) 1. (102) reduce, cut down, cut back, trim, trim down, trim back, cut, bring down -- (cut down on; make a reduction in; "reduce your daily fat intake"; "The employer wants to cut back health benefits") 2. (9) reduce -- (make less complex; "reduce a problem to a single question") 3. (5) reduce -- (bring to humbler or weaker state or condition; "He reduced the population to slavery") 4. (3) reduce -- (simplify the form of a mathematical equation of expression by substituting one term for another) 5. (3) reduce -- (lower in grade or rank or force somebody into an undignified situation; "She reduced her niece to a servant") 6. (3) reduce, come down, boil down -- (be the essential element; "The proposal boils down to a compromise") 7. (2) shrink, reduce -- (reduce in size; reduce physically; "Hot water will shrink the sweater"; "Can you shrink this image?") 8. (1) reduce -- (lessen and make more modest; "reduce one's standard of living") 9. (1) reduce, scale down -- (make smaller; "reduce an image") 10. (1) deoxidize, deoxidise, reduce -- (to remove oxygen from a compound, or cause to react with hydrogen or form a hydride, or to undergo an increase in the number of electrons) 11. (1) reduce, tighten -- (narrow or limit; "reduce the influx of foreigners") 12. repress, quash, keep down, subdue, subjugate, reduce -- (put down by force or intimidation; "The government quashes any attempt of an uprising"; "China keeps down her dissidents very efficiently"; "The rich landowners subjugated the peasants working the land") 13. reduce -- (undergo meiosis; "The cells reduce") 14. reduce -- (reposition (a broken bone after surgery) back to its normal site) 15. reduce -- (destress and thus weaken a sound when pronouncing it) 16. abridge, foreshorten, abbreviate, shorten, cut, contract, reduce -- (reduce in scope while retaining essential elements; "The manuscript must be shortened") 17. boil down, reduce, decoct, concentrate -- (be cooked until very little liquid is left; "The sauce should reduce to one cup") 18. reduce, boil down, concentrate -- (cook until very little liquid is left; "The cook reduced the sauce by boiling it for a long time") 19. dilute, thin, thin out, reduce, cut -- (lessen the strength or flavor of a solution or mixture; "cut bourbon") 20. reduce, melt off, lose weight, slim, slenderize, thin, slim down -- (take off weight) Overview of adj reduced The adj reduced has 2 senses (first 2 from tagged texts) 1. (6) decreased, reduced -- (made less in size or amount or degree) 2. (1) reduced, rock-bottom -- (well below normal (especially in price)) --- WordNet end ---