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358) Both polymers have recently been described as a template that induces an increased expression of the genes encoding bone morphogenetic protein 2 (BMP-2) and osteoprotegerin in osteoblast-related SaOS-2 cells; simultaneously or subsequently the cells respond with enhanced hydroxyapatite formation.
2015 Journal of tissue engineering and regenerative medicine
* Development of a morphogenetically active scaffold for three-dimensional growth of bone cells: biosilica-alginate hydrogel for SaOS-2 cell cultivation.
- Polymeric silica is formed from ortho-silicate during a sol-gel formation process, while biosilica is the product of an enzymatically driven bio-polycondensation reaction. Both polymers have recently been described as a template that induces an increased expression of the genes encoding bone morphogenetic protein 2 (BMP-2) and osteoprotegerin in osteoblast-related SaOS-2 cells; simultaneously or subsequently the cells respond with enhanced hydroxyapatite formation. In order to assess whether the biocompatible polymeric silica/biosilica can serve as a morphogenetically active matrix suitable for three-dimensional (3D) cell growth, or even for 3D cell bioprinting, SaOS-2 cells were embedded into a Na-alginate-based hydrogel. Four different gelatinous hydrogel matrices were used for suspending SaOS-2 cells: (a) the hydrogel alone; (b) the hydrogel with 400 μM ortho-silicate; (c) the hydrogel supplemented with 400 μM ortho-silicate and recombinant silicatein to allow biosilica synthesis to occur; and (d) the hydrogel with ortho-silicate and BSA. The SaOS-2 cells showed an increased growth if silica/biosilica components were present in the hydrogel. Likewise intensified was the formation of hydroxyapatite nodules in the silica-containing hydrogels. After an incubation period of 2 weeks, cells present in silica-containing hydrogels showed a significantly higher expression of the genes encoding the cytokine BMP-2, the major fibrillar structural protein collagen 1 and likewise of carbonic anhydrase. It is concluded that silica, and to a larger extent biosilica, retains its morphogenetic/osteogenic potential after addition to Na-alginate-based hydrogels. This property might qualify silica hydrogels to be also used as a matrix for 3D cell printing.
=>1.関係のある, 関連した, 2.同族の, 親類関係にある
Overview of verb relate
The verb relate has 5 senses (first 5 from tagged texts)
1. (15) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal
connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I
cannot relate these events at all")
2. (9) refer, pertain, relate, concern, come to, bear on, touch, touch on, have-to doe with -- (be
relevant to; "There were lots of questions referring to her talk"; "My remark pertained to your
earlier comments")
3. (7) relate -- (give an account of; "The witness related the events")
4. (4) relate, interrelate -- (be in a relationship with; "How are these two observations related?")
5. (2) relate -- (have or establish a relationship to; "She relates well to her peers")
Overview of adj related
The adj related has 2 senses (first 2 from tagged texts)
1. (20) related, related to -- (being connected either logically or causally or by shared
characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle
formation is the...ability of detergent actives to congregate at oil-water interfaces")
2. (4) related -- (connected by kinship, common origin, or marriage)
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