ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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273413 occurrences (No.92 in the rank) during 5 years in the PubMed. [cache]
362) Finally, in both prefrontal and MTL regions, white-matter decline and success-related activations occurred in close proximity and were negatively correlated.
* Less wiring, more firing: low-performing older adults compensate for impaired white matter with greater neural activity.
- The reliable neuroimaging finding that older adults often show greater activity (over-recruitment) than younger adults is typically attributed to compensation. Yet, the neural mechanisms of over-recruitment in older adults (OAs) are largely unknown. Rodent electrophysiology studies have shown that as number of afferent fibers within a circuit decreases with age, the fibers that remain show higher synaptic field potentials (less wiring, more firing). Extrapolating to system-level measures in humans, we proposed and tested the hypothesis that greater activity in OAs compensates for impaired white-matter connectivity. Using a neuropsychological test battery, we measured individual differences in executive functions associated with the prefrontal cortex (PFC) and memory functions associated with the medial temporal lobes (MTLs). Using event-related functional magnetic resonance imaging, we compared activity for successful versus unsuccessful trials during a source memory task. Finally, we measured white-matter integrity using diffusion tensor imaging. The study yielded 3 main findings. First, low-executive OAs showed greater success-related activity in the PFC, whereas low-memory OAs showed greater success-related activity in the MTLs. Second, low-executive OAs displayed white-matter deficits in the PFC, whereas low-memory OAs displayed white-matter deficits in the MTLs. Finally, in both prefrontal and MTL regions, white-matter decline and success-related activations occurred in close proximity and were negatively correlated. This finding supports the less-wiring-more-firing hypothesis, which provides a testable account of compensatory over-recruitment in OAs.
=>1.関係のある, 関連した, 2.同族の, 親類関係にある
Overview of verb relate
The verb relate has 5 senses (first 5 from tagged texts)
1. (15) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal
connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I
cannot relate these events at all")
2. (9) refer, pertain, relate, concern, come to, bear on, touch, touch on, have-to doe with -- (be
relevant to; "There were lots of questions referring to her talk"; "My remark pertained to your
earlier comments")
3. (7) relate -- (give an account of; "The witness related the events")
4. (4) relate, interrelate -- (be in a relationship with; "How are these two observations related?")
5. (2) relate -- (have or establish a relationship to; "She relates well to her peers")
Overview of adj related
The adj related has 2 senses (first 2 from tagged texts)
1. (20) related, related to -- (being connected either logically or causally or by shared
characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle
formation is the...ability of detergent actives to congregate at oil-water interfaces")
2. (4) related -- (connected by kinship, common origin, or marriage)
--- WordNet end ---