ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for research out of >500 occurrences
280501 occurrences (No.89 in the rank) during 5 years in the PubMed. [no cache]
500 found
170) Interspecies somatic cell nuclear transfer (iSCNT), a powerful tool in basic scientific research, has been used widely to increase and preserve the population of endangered species.
* Sodium butyrate improves the cloned yak embryo viability and corrects gene expression patterns.
- Interspecies somatic cell nuclear transfer (iSCNT), a powerful tool in basic scientific research, has been used widely to increase and preserve the population of endangered species. Yak (Bos grunniens) is one of these species. Development to term of interspecies cloned yak embryos has not been achieved, possibly due to abnormal epigenetic reprogramming. Previous studies have demonstrated that treatment of intraspecies cloned embryos with (NaBu) significantly improves nuclear-cytoplasmic reprogramming and viability in vitro. Therefore, in this study, we evaluated the effect of optimal NaBu concentration and exposure time on preimplantation development of yak iSCNT embryos and on the expression patterns of developmentally important genes. The results showed that 8-cell rate, blastocyst formation rate and total cell number increased significantly compared with their untreated counterparts when yak iSCNT embryos were treated with 5 nM NaBu for 12 h after activation, but that the 2-cell stage embryo rate was not significantly different. The treatment of NaBu also increased significantly the expression levels of Oct-4 and decreased the expression levels of HDAC-2, Dnmt-1 and IGF-1; the expression patterns of these genes were more similar to that of their bovine-yak in vitro fertilization (BY-IVF) counterparts. The results described above indicated that NaBu treatment improved developmental competence in vitro and 'corrected' the gene expression patterns of yak iSCNT embryos.
=>調査する, 研究(する), 探求, 調査, 捜索, 研究する
Overview of noun research
The noun research has 2 senses (first 2 from tagged texts)
1. (46) research -- (systematic investigation to establish facts)
2. (6) inquiry, enquiry, research -- (a search for knowledge; "their pottery deserves more research
than it has received")
Overview of verb research
The verb research has 2 senses (first 1 from tagged texts)
1. (1) research -- (attempt to find out in a systematically and scientific manner; "The student
researched the history of that word")
2. research, search, explore -- (inquire into; "the students had to research the history of the
Second World War for their history project"; "He searched for information on his relatives on the
web"; "Scientists are exploring the nature of consciousness")
--- WordNet end ---