ELIZA

return kwic search for research out of >500 occurrences
280501 occurrences (No.89 in the rank) during 5 years in the PubMed. [no cache] 500 found

192) The aim of the present research was to demonstrate the presence of TRPV1 in human and canine mammary cancer cells, MCF-7 and CF.41, respectively, and to study the role of TRPV1 in regulating cell proliferation.

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PMID:23510405 DOI:10.1111/vco.12028

2015 Veterinary and comparative oncology

* Expression and functionality of TRPV1 receptor in human MCF-7 and canine CF.41 cells.

- As canine mammary tumours (CMT) and human breast cancer share clinical and prognostic features, the former have been proposed as a model to study carcinogenesis and improved therapeutic treatment in human breast cancer. In recent years, it has been shown that transient receptor potential vanilloid 1 (TRPV1) is expressed in different neoplastic tissues and its activation has been associated with regulation of cancer growth and progression. The aim of the present research was to demonstrate the presence of TRPV1 in human and canine mammary cancer cells, MCF-7 and CF.41, respectively, and to study the role of TRPV1 in regulating cell proliferation. The images obtained by Western blot showed a signal at 100 kDa corresponding to the molecular weight of TRPV1 receptor. All tested TRPV1 agonists and antagonists caused a significant decrease (P < 0.05) of cell growth rate in MCF-7 cells. By contrast, in CF.41 cells capsaicin and capsazepine induced a significant increase (P < 0.05) in cell proliferation, whereas resiniferatoxin (RTX) and 5-iodo-resiniferatoxin (5-I-RTX) had no influence on CF.41 cell proliferation. Further studies are needed to elucidate the underlying molecular mechanism responsible for the different effects evoked by TRPV1 activation in MCF-7 and CF.41 cells.

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(1)42 null	(14)7 that	(27)3 as	(40)2 from
(2)40 on	(15)6 by	(28)3 directions	(41)2 involving
(3)36 is	(16)6 to	(29)3 evidence	(42)2 participants,
(4)27 and	(17)5 projects	(30)3 have	(43)2 progress
(5)25 has	(18)4 culture	(31)3 method	(44)2 sponsored
(6)14 in	(19)4 design	(32)3 results	(45)2 the
(7)12 was	(20)4 findings	(33)3 shows	(46)2 topic
(8)11 are	(21)4 needs	(34)3 study	(47)2 towards
(9)11 should	(22)4 project	(35)3 will	(48)2 trends
(10)9 into	(23)4 questions	(36)2 efforts	(49)2 using
(11)9 with	(24)4 regarding	(37)2 examined	(50)2 we
(12)8 studies	(25)3 &	(38)2 focus	(51)2 work
(13)8 suggests	(26)3 aimed	(39)2 for

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--- WordNet output for research --- =>調査する, 研究(する), 探求, 調査, 捜索, 研究する Overview of noun research The noun research has 2 senses (first 2 from tagged texts) 1. (46) research -- (systematic investigation to establish facts) 2. (6) inquiry, enquiry, research -- (a search for knowledge; "their pottery deserves more research than it has received") Overview of verb research The verb research has 2 senses (first 1 from tagged texts) 1. (1) research -- (attempt to find out in a systematically and scientific manner; "The student researched the history of that word") 2. research, search, explore -- (inquire into; "the students had to research the history of the Second World War for their history project"; "He searched for information on his relatives on the web"; "Scientists are exploring the nature of consciousness") --- WordNet end ---