ELIZA

return kwic search for research out of >500 occurrences
280501 occurrences (No.89 in the rank) during 5 years in the PubMed. [cache]

229) Further, to gain traction on prevention and treatment, additional research to identify motivational and neurobiological drivers and consequences of comorbid use is needed.

--- ABSTRACT ---

PMID:34543650 DOI:10.1016/j.neubiorev.2021.09.019

2021 Neuroscience and biobehavioral reviews

* Combined and sequential effects of alcohol and methamphetamine in animal models.

- Comorbid drug use, often alcohol with other drugs, poses significant health and societal concerns. Methamphetamine is among the illicit drugs most often co-used with alcohol. The current review examines the animal literature for impacts of comorbid alcohol and methamphetamine exposure. We found evidence for additive or synergistic effects of combined or sequential exposure on behavior and physiology. Dopaminergic, serotonergic, and glutamatergic systems are all impacted by combined exposure to alcohol and methamphetamine and cyclooxygenase-2 activity plays an important role in their combined neurotoxic effects. Adverse consequences of comorbid exposure include altered brain development with prenatal exposure, impaired learning and memory, motor deficits, gastrotoxicity, hepatotoxicity, and augmented intake under some conditions. Given high susceptibility to drug experimentation in adolescence, studies of co-exposure during the adolescent period and of how adolescent exposure to one drug impacts later use or sensitivity to the other drug should be a priority. Further, to gain traction on prevention and treatment, additional research to identify motivational and neurobiological drivers and consequences of comorbid use is needed.

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[frequency of next (right) word to research]

(1)43 null	(16)5 literature	(31)3 papers	(46)2 needs
(2)40 in	(17)5 was	(32)3 published	(47)2 participants
(3)38 is	(18)4 as	(33)3 regarding	(48)2 project
(4)32 on	(19)4 findings	(34)3 settings	(49)2 question
(5)29 and	(20)4 into	(35)2 Network	(50)2 question,
(6)16 has	(21)4 methods	(36)2 aims	(51)2 questions:
(7)15 should	(22)4 that	(37)2 area	(52)2 reports
(8)10 studies	(23)4 we	(38)2 available	(53)2 requires
(9)9 to	(24)3 activity	(39)2 capacity	(54)2 supporting
(10)7 gaps	(25)3 agenda	(40)2 design,	(55)2 synthesis
(11)7 questions	(26)3 areas	(41)2 efforts	(56)2 team
(12)6 are	(27)3 design	(42)2 efforts,	(57)2 waste
(13)6 articles	(28)3 designs	(43)2 fields
(14)5 about	(29)3 evidence	(44)2 included
(15)5 conducted	(30)3 from	(45)2 indicates

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--- WordNet output for research --- =>調査する, 研究(する), 探求, 調査, 捜索, 研究する Overview of noun research The noun research has 2 senses (first 2 from tagged texts) 1. (46) research -- (systematic investigation to establish facts) 2. (6) inquiry, enquiry, research -- (a search for knowledge; "their pottery deserves more research than it has received") Overview of verb research The verb research has 2 senses (first 1 from tagged texts) 1. (1) research -- (attempt to find out in a systematically and scientific manner; "The student researched the history of that word") 2. research, search, explore -- (inquire into; "the students had to research the history of the Second World War for their history project"; "He searched for information on his relatives on the web"; "Scientists are exploring the nature of consciousness") --- WordNet end ---