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return kwic search for response out of >500 occurrences
343831 occurrences (No.54 in the rank) during 5 years in the PubMed. [cache]

149) Broad tufted pyramidal neurons with little spike adaptation showed a small adenosine response, whereas slender tufted pyramidal neurons with substantial adaptation showed a bigger response.

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PMID:24108800 DOI:10.1093/cercor/bht274

2015 Cerebral cortex (New York, N.Y. : 1991)

* Cell type-specific effects of adenosine on cortical neurons.

- The neuromodulator adenosine is widely considered to be a key regulator of sleep homeostasis and an indicator of sleep need. Although the effect of adenosine on subcortical areas has been previously described, the effects on cortical neurons have not been addressed systematically to date. To that purpose, we performed in vitro whole-cell patch-clamp recordings and biocytin staining of pyramidal neurons and interneurons throughout all layers of rat prefrontal and somatosensory cortex, followed by morphological analysis. We found that adenosine, via the A1 receptor, exerts differential effects depending on neuronal cell type and laminar location. Interneurons and pyramidal neurons in layer 2 and a subpopulation of layer 3 pyramidal neurons that displayed regular spiking were insensitive to adenosine application, whereas other pyramidal cells in layers 3-6 were hyperpolarized (range 1.2-10.8 mV). Broad tufted pyramidal neurons with little spike adaptation showed a small adenosine response, whereas slender tufted pyramidal neurons with substantial adaptation showed a bigger response. These studies of the action of adenosine at the postsynaptic level may contribute to the understanding of the changes in cortical circuit functioning that take place between sleep and awakening.

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(1)146 to	(14)4 proteins	(27)3 time	(40)2 following
(2)32 null	(15)4 rates	(28)3 times	(41)2 from
(3)31 and	(16)4 that	(29)3 which	(42)2 including
(4)22 of	(17)4 the	(30)2 (ABR)	(43)2 latency
(5)21 rate	(18)3 at	(31)2 (DDR)	(44)2 mediated
(6)14 was	(19)3 during	(32)2 (UPR)	(45)2 or
(7)13 in	(20)3 elements	(33)2 after	(46)2 rate)
(8)8 selection	(21)3 models	(34)2 are	(47)2 rates,
(9)7 surface	(22)3 options	(35)2 boundaries	(48)2 such
(10)6 data	(23)3 properties	(36)2 delays	(49)2 theory
(11)6 is	(24)3 strategies	(37)2 effects	(50)2 validity
(12)4 for	(25)3 style	(38)2 element	(51)2 were
(13)4 patterns	(26)3 suppression	(39)2 evaluation

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--- WordNet output for response --- =>反応, 応答, 返答, 返報, 反響, 答唱句 Overview of noun response The noun response has 7 senses (first 5 from tagged texts) 1. (11) response -- (a result; "this situation developed in response to events in Africa") 2. (11) reaction, response -- (a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age") 3. (6) answer, reply, response -- (a statement (either spoken or written) that is made to reply to a question or request or criticism or accusation; "I waited several days for his answer"; "he wrote replies to several of his critics") 4. (4) reception, response -- (the manner in which something is greeted; "she did not expect the cold reception she received from her superiors") 5. (1) response -- (a phrase recited or sung by the congregation following a versicle by the priest or minister) 6. reply, response -- (the speech act of continuing a conversational exchange; "he growled his reply") 7. response -- (the manner in which an electrical or mechanical device responds to an input signal or a range of input signals) --- WordNet end ---