ELIZA

return kwic search for response out of >500 occurrences
343831 occurrences (No.54 in the rank) during 5 years in the PubMed. [no cache] 500 found

156) Higher BMI, baseline HCV viral load and leptin levels were associated with lack of sustained virologic response.

--- ABSTRACT ---

PMID:24506344 DOI:10.1111/jvh.12226

2015 Journal of viral hepatitis

* Acute and chronic immune biomarker changes during interferon/ribavirin treatment in HIV/HCV co-infected patients.

- Chronic viral infections lead to persistent immune activation, which is alleviated by eradicating or suppressing the infection. To understand the effects of interferon treatment on immune system activation by chronic infections, we evaluated kinetic patterns of a broad spectrum of serum biomarkers during HCV treatment in HIV/HCV co-infected patients. HCV viral load and 50 biomarkers were analysed at baseline and 27 time points during pegylated interferon-alpha and ribavirin (IFN/RBV) treatment of 12 HIV/HCV co-infected patients. We evaluated biomarker changes from baseline for each time point and biomarker correlations with clinical parameters, treatment response and liver histopathology. IL-1α, IL-12p40, IL-1RA, IP-10, MIG, MIP-1α/1β, HGF, sCD40L, TRAIL and leptin increased in the first day. IL-12p70, IL-17A, IL-10, GROα, IL-8, MCP-3, IL-4 and M-CSF peaked later during week 1. IL-1α, HGF, IP-10, MIP-1α, TRAIL, sCD40L, IL-10, IL-12p70, MCP-3, FGFb, ENA-78, TGF-β, IL-2, IFN-γ, IL-6, IL-15, IL-7 and PDGF-BB decreased below baseline over the course of treatment. Higher BMI, baseline HCV viral load and leptin levels were associated with lack of sustained virologic response. ENA-78 was associated with sustained viral response. Positive correlations were found between liver inflammation and baseline CD4 count, sVCAM and HGF; fibrosis stage and HGF; liver steatosis, BMI and leptin. Our findings suggest IFN/RBV treatment initially increases levels of several biomarkers, but eventually leads to a decline in many immune markers. These findings shed light on the relationship between IFN treatment and immune activation by chronic viral infections, such as HCV.

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(1)146 to	(14)4 proteins	(27)3 time	(40)2 following
(2)32 null	(15)4 rates	(28)3 times	(41)2 from
(3)31 and	(16)4 that	(29)3 which	(42)2 including
(4)22 of	(17)4 the	(30)2 (ABR)	(43)2 latency
(5)21 rate	(18)3 at	(31)2 (DDR)	(44)2 mediated
(6)14 was	(19)3 during	(32)2 (UPR)	(45)2 or
(7)13 in	(20)3 elements	(33)2 after	(46)2 rate)
(8)8 selection	(21)3 models	(34)2 are	(47)2 rates,
(9)7 surface	(22)3 options	(35)2 boundaries	(48)2 such
(10)6 data	(23)3 properties	(36)2 delays	(49)2 theory
(11)6 is	(24)3 strategies	(37)2 effects	(50)2 validity
(12)4 for	(25)3 style	(38)2 element	(51)2 were
(13)4 patterns	(26)3 suppression	(39)2 evaluation

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--- WordNet output for response --- =>反応, 応答, 返答, 返報, 反響, 答唱句 Overview of noun response The noun response has 7 senses (first 5 from tagged texts) 1. (11) response -- (a result; "this situation developed in response to events in Africa") 2. (11) reaction, response -- (a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age") 3. (6) answer, reply, response -- (a statement (either spoken or written) that is made to reply to a question or request or criticism or accusation; "I waited several days for his answer"; "he wrote replies to several of his critics") 4. (4) reception, response -- (the manner in which something is greeted; "she did not expect the cold reception she received from her superiors") 5. (1) response -- (a phrase recited or sung by the congregation following a versicle by the priest or minister) 6. reply, response -- (the speech act of continuing a conversational exchange; "he growled his reply") 7. response -- (the manner in which an electrical or mechanical device responds to an input signal or a range of input signals) --- WordNet end ---