ELIZA

return kwic search for revealed out of >500 occurrences
324965 occurrences (No.62 in the rank) during 5 years in the PubMed. [cache]

222) These results revealed a non-centered process in relation to the average target (100% w/w), in the specified range (85-115%).

--- ABSTRACT ---

PMID:24344991 DOI:10.3109/10837450.2013.867448

2015 Pharmaceutical development and technology

* The critical role of NIR spectroscopy and statistical process control (SPC) strategy towards captopril tablets (25 mg) manufacturing process understanding: a case study.

- In this work, near-infrared spectroscopy (NIRS) method was used to evaluate the uniformity of dosage units of three captopril 25 mg tablets commercial batches. The performance of the calibration method was assessed by determination of Q value (0.9986), standard error of estimation (C-set SEE = 1.956), standard error of prediction (V-set SEP = 2.076) as well as the consistency (106.1%). These results indicated the adequacy of the selected model. The method validation revealed the agreement of the reference high pressure liquid chromatography (HPLC) and NIRS methods. The process evaluation using the NIRS method showed that the variability was due to common causes and delivered predictable results consistently. Cp and Cpk values were, respectively, 2.05 and 1.80. These results revealed a non-centered process in relation to the average target (100% w/w), in the specified range (85-115%). The probability of failure was 21:100 million tablets of captopril. The NIRS in combination with the method of multivariate calibration, partial least squares (PLS) regression, allowed the development of methodology for the uniformity of dosage units evaluation of captopril tablets 25 mg. The statistical process control strategy associated with NIRS method as PAT played a critical role in understanding of the sources and degree of variation and its impact on the process. This approach led towards a better process understanding and provided the sound scientific basis for its continuous improvement.

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[frequency of next (right) word to revealed]

(1)193 that	(9)4 five	(17)2 common	(25)2 new
(2)61 a	(10)4 high	(18)2 distinct	(26)2 numerous
(3)21 the	(11)3 statistically	(19)2 enhanced	(27)2 right
(4)14 no	(12)3 that,	(20)2 evidence	(28)2 severe
(5)13 an	(13)3 three	(21)2 four	(29)2 significantly
(6)13 significant	(14)3 two	(22)2 higher
(7)7 by	(15)2 null	(23)2 in
(8)5 multiple	(16)2 as	(24)2 moderate

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--- WordNet output for revealed --- Overview of verb reveal The verb reveal has 3 senses (first 2 from tagged texts) 1. (34) uncover, bring out, unveil, reveal -- (make visible; "Summer brings out bright clothes"; "He brings out the best in her") 2. (17) unwrap, disclose, let on, bring out, reveal, discover, expose, divulge, break, give away, let out -- (make known to the public information that was previously known only to a few people or that was meant to be kept a secret; "The auction house would not disclose the price at which the van Gogh had sold"; "The actress won't reveal how old she is"; "bring out the truth"; "he broke the news to her"; "unwrap the evidence in the murder case") 3. reveal -- (disclose directly or through prophets; "God rarely reveal his plans for Mankind") --- WordNet end ---