* TMC4 is a novel chloride channel involved in high-concentration salt taste sensation.
- "Salty taste" sensation is evoked when sodium and chloride ions are present together in the oral cavity. The presence of an epithelial cation channel that receives Na+ has previously been reported. However, no molecular entity involving Cl- receptors has been elucidated. We report the strong expression of transmembrane channel-like 4 (TMC4) in the circumvallate and foliate papillae projected to the glossopharyngeal nerve, mediating a high-concentration of NaCl. Electrophysiological analysis using HEK293T cells revealed that TMC4 was a voltage-dependent Cl- channel and the consequent currents were completely inhibited by NPPB, an anion channel blocker. TMC4 allowed permeation of organic anions including gluconate, but their current amplitudes at positive potentials were less than that of Cl-. Tmc4-deficient mice showed significantly weaker glossopharyngeal nerve response to high-concentration of NaCl than the wild-type littermates. These results indicated that TMC4 is a novel chloride channel that responds to high-concentration of NaCl.
Overview of verb show
The verb show has 12 senses (first 11 from tagged texts)
1. (136) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested
audience; "She shows her dogs frequently"; "We will demo the new software in Washington")
2. (63) prove, demonstrate, establish, show, shew -- (establish the validity of something, as by an
example, explanation or experiment; "The experiment demonstrated the instability of the compound";
"The mathematician showed the validity of the conjecture")
3. (57) testify, bear witness, prove, evidence, show -- (provide evidence for; "The blood test
showed that he was the father"; "Her behavior testified to her incompetence")
4. (43) show -- (make visible or noticeable; "She showed her talent for cooking"; "Show me your
etchings, please")
5. (32) picture, depict, render, show -- (show in, or as in, a picture; "This scene depicts country
life"; "the face of the child is rendered with much tenderness in this painting")
6. (24) express, show, evince -- (give expression to; "She showed her disappointment")
7. (24) indicate, point, designate, show -- (indicate a place, direction, person, or thing; either
spatially or figuratively; "I showed the customer the glove section"; "He pointed to the empty
parking space"; "he indicated his opponents")
8. (11) show, show up -- (be or become visible or noticeable; "His good upbringing really shows";
"The dirty side will show")
9. (7) read, register, show, record -- (indicate a certain reading; of gauges and instruments; "The
thermometer showed thirteen degrees below zero"; "The gauge read `empty'")
10. (6) show -- (give evidence of, as of records; "The diary shows his distress that evening")
11. (2) usher, show -- (take (someone) to their seats, as in theaters or auditoriums; "The usher
showed us to our seats")
12. show -- (finish third or better in a horse or dog race; "he bet $2 on number six to show")
--- WordNet end ---