ELIZA

return kwic search for significant out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [cache]

75) This 2020 Roadmap update reviews the significant changes since 2017 and identifies priority areas for achieving the goals of reducing death and disability related to AF, particularly targeted at low-middle income countries.

--- ABSTRACT ---

PMID:34211827 DOI:10.5334/gh.1023

2021 Global heart

* World Heart Federation Roadmap on Atrial Fibrillation - A 2020 Update.

- The World Heart Federation (WHF) commenced a Roadmap initiative in 2015 to reduce the global burden of cardiovascular disease and resultant burgeoning of healthcare costs. Roadmaps provide a blueprint for implementation of priority solutions for the principal cardiovascular diseases leading to death and disability. Atrial fibrillation (AF) is one of these conditions and is an increasing problem due to ageing of the world's population and an increase in cardiovascular risk factors that predispose to AF. The goal of the AF roadmap was to provide guidance on priority interventions that are feasible in multiple countries, and to identify roadblocks and potential strategies to overcome them. Since publication of the AF Roadmap in 2017, there have been many technological advances including devices and artificial intelligence for identification and prediction of unknown AF, better methods to achieve rhythm control, and widespread uptake of smartphones and apps that could facilitate new approaches to healthcare delivery and increasing community AF awareness. In addition, the World Health Organisation added the non-vitamin K antagonist oral anticoagulants (NOACs) to the Essential Medicines List, making it possible to increase advocacy for their widespread adoption as therapy to prevent stroke. These advances motivated the WHF to commission a 2020 AF Roadmap update. Three years after the original Roadmap publication, the identified barriers and solutions were judged still relevant, and progress has been slow. This 2020 Roadmap update reviews the significant changes since 2017 and identifies priority areas for achieving the goals of reducing death and disability related to AF, particularly targeted at low-middle income countries. These include advocacy to increase appreciation of the scope of the problem; plugging gaps in guideline management and prevention through physician education, increasing patient health literacy, and novel ways to increase access to integrated healthcare including mHealth and digital transformations; and greater emphasis on achieving practical solutions to national and regional entrenched barriers. Despite the advances reviewed in this update, the task will not be easy, but the health rewards of implementing solutions that are both innovative and practical will be great.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to significant]

(1)20 increase	(21)5 and	(41)2 DDIs	(61)2 heterogeneity
(2)16 differences	(22)5 improvement	(42)2 adverse	(62)2 impacts
(3)15 difference	(23)5 results	(43)2 antioxidant	(63)2 impairment
(4)13 reduction	(24)5 risk	(44)2 at	(64)2 implications
(5)11 changes	(25)4 amount	(45)2 barriers	(65)2 increased
(6)10 association	(26)4 associations	(46)2 being	(66)2 induction
(7)10 improvements	(27)4 burden	(47)2 benefits	(67)2 interaction
(8)10 positive	(28)4 clinical	(48)2 cause	(68)2 loci
(9)10 role	(29)4 public	(49)2 challenges	(69)2 morbidity
(10)9 impact	(30)3 advances	(50)2 clusters	(70)2 number
(11)8 decrease	(31)3 as	(51)2 cognitive	(71)2 personal
(12)8 in	(32)3 evidence	(52)2 consequence	(72)2 portion
(13)7 null	(33)3 expression	(53)2 contribution	(73)2 relationship
(14)7 effect	(34)3 gaps	(54)2 correlation	(74)2 sequence
(15)6 effects	(35)3 health	(55)2 factor	(75)2 survival
(16)6 increases	(36)3 highly	(56)2 finding	(76)2 than
(17)6 progress	(37)3 inhibition	(57)2 findings	(77)2 therapeutic
(18)6 proportion	(38)3 interactions	(58)2 for	(78)2 trend
(19)6 reductions	(39)3 predictors	(59)2 fraction	(79)2 variation
(20)5 (p	(40)3 upregulation	(60)2 functional	(80)2 variations

add keyword

--- WordNet output for significant --- =>意義深い, 重大な, 意味のある, 意味ありげな, 重要な Overview of adj significant The adj significant has 4 senses (first 4 from tagged texts) 1. (18) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 2. (9) significant, substantial -- (fairly large; "won by a substantial margin") 3. (3) significant -- (too closely correlated to be attributed to chance and therefore indicating a systematic relation; "the interaction effect is significant at the .01 level"; "no significant difference was found") 4. (2) meaning, pregnant, significant -- (rich in significance or implication; "a meaning look") --- WordNet end ---