2015 American journal of Alzheimer's disease and other dementias
* Elevated Galectin-3 Levels in the Serum of Patients With Alzheimer's Disease.
- Alzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system. Galectin-3 (Gal-3) is characterized by a conserved sequence within the carbohydrate recognition domain. The effect of Gal-3 in AD is presently unknown. In this study, we found significantly increased Gal-3 serum levels in patients with AD compared to control participants (P=.017). There was no significant difference between patients with mild cognitive impairment (MCI) and healthy controls (P=.143) or between patients with AD and MCI (P=.688). The degree of cognitive impairment, as measured by the Mini-Mental Status Examination score, was found to have a significant correlation with the Gal-3 serum levels in all patients and healthy controls. These data suggest that Gal-3 potentially plays a role in the neuropathogenesis of AD. The Gal-3 found in serum could be a potential candidate for a biomarker panel for AD diagnosis.
=>きわめて, 意味深く, 意味ありげに
Overview of adv significantly
The adv significantly has 3 senses (first 2 from tagged texts)
1. (6) significantly -- (in a statistically significant way; "the two groups differed
significantly")
2. (3) significantly -- (in a significant manner; "our budget will be significantly affected by
these new cuts")
3. importantly, significantly -- (in an important way or to an important degree; "more importantly,
Weber held that the manifold meaning attached to the event by the social scientist could alter his
definition of the concrete event itself")
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