ELIZA

return kwic search for significantly out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [cache]

435) We have discovered that oral DHF supplementation significantly attenuates fat mass, hepatic lipid accumulation, and adipose tissue inflammation in female mice.

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PMID:33669347 DOI:10.3390/nu13020637

2021 Nutrients

* Sex-Dependent Effects of 7,8-Dihydroxyflavone on Metabolic Health Are Associated with Alterations in the Host Gut Microbiome.

- 7,8-Dihydroxyflavone (DHF) is a naturally occurring flavonoid that has been reported to protect against a variety of pathologies. Chronic administration of DHF prevents high-fat diet (HFD)-induced obesity in female, but not male, mice. However, the mechanisms underlying this sexual dimorphism have not been elucidated. We have discovered that oral DHF supplementation significantly attenuates fat mass, hepatic lipid accumulation, and adipose tissue inflammation in female mice. In contrast, male mice were not protected from adiposity, and had a paradoxical worsening of hepatic lipid accumulation and adipose tissue inflammation upon DHF supplementation. Consistent with these sexually dimorphic effects on body weight and metabolic health, 7,8-DHF induced early and stable remodeling of the female intestinal microbiome. DHF supplementation significantly increased gut microbial diversity, and suppressed potentially detrimental bacteria, particularly Desulfovibrionaceae, which are pro-inflammatory and positively associated with obesity and inflammation. Changes in the female gut microbiome preceded alterations in body weights, and in silico analyses indicated that these early microbial changes were highly predictive of subsequent weight gain in female mice. While some alterations in the intestinal microbiome were also observed in male DHF-supplemented mice, these changes were distinct from those in females and, importantly, were not predictive of subsequent body weight changes in male animals. The temporality of microbial changes preceding alterations in body weight in female mice suggests a role for the gut microbiome in mediating the sexually dimorphic effects of DHF on body weight. Given the significant clinical interest in this flavonoid across a wide range of pathologies, further elucidation of these sexually dimorphic effects will aid the development of effective clinical therapies.

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(1)44 higher	(17)6 with	(33)4 in	(49)2 faster
(2)35 increased	(18)5 and	(34)4 suppressed	(50)2 increases
(3)33 associated	(19)5 better	(35)3 (p	(51)2 influence
(4)25 reduced	(20)5 enhanced	(36)3 change	(52)2 inhibit
(5)20 lower	(21)5 enriched	(37)3 diminished	(53)2 larger
(6)19 decreased	(22)5 less	(38)3 increase	(54)2 lowered
(7)15 different	(23)5 related	(39)3 longer	(55)2 modified
(8)14 more	(24)4 null	(40)2 (P	(56)2 over
(9)13 greater	(25)4 altered	(41)2 affected	(57)2 positively
(10)12 improved	(26)4 between	(42)2 alleviated	(58)2 prolong
(11)11 correlated	(27)4 by	(43)2 alter	(59)2 reduce
(12)10 inhibited	(28)4 downregulated	(44)2 at	(60)2 reduces
(13)6 attenuated	(29)4 elevated	(45)2 changed	(61)2 reversed
(14)6 predicted	(30)4 impact	(46)2 declined
(15)6 to	(31)4 improve	(47)2 decreased,
(16)6 upregulated	(32)4 improves	(48)2 expanded

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--- WordNet output for significantly --- =>きわめて, 意味深く, 意味ありげに Overview of adv significantly The adv significantly has 3 senses (first 2 from tagged texts) 1. (6) significantly -- (in a statistically significant way; "the two groups differed significantly") 2. (3) significantly -- (in a significant manner; "our budget will be significantly affected by these new cuts") 3. importantly, significantly -- (in an important way or to an important degree; "more importantly, Weber held that the manifold meaning attached to the event by the social scientist could alter his definition of the concrete event itself") --- WordNet end ---