ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for species out of >500 occurrences
321753 occurrences (No.65 in the rank) during 5 years in the PubMed. [no cache] 500 found
159) Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere erosion and mitochondrial injury, leading to impaired cellular functions and cell death.
--- ABSTRACT ---
PMID:34752684 DOI:10.1111/acel.13513
2021 Aging cell
* Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells.
- Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere erosion and mitochondrial injury, leading to impaired cellular functions and cell death. Whether oxidative stress-mediated telomere erosion induces mitochondrial injury, or vice versa, in human T cells-the major effectors of host adaptive immunity against infection and malignancy-is poorly understood due to the pleiotropic effects of ROS. Here we employed a novel chemoptogenetic tool that selectively produces a single oxygen (1 O2 ) only at telomeres or mitochondria in Jurkat T cells. We found that targeted 1 O2 production at telomeres triggered not only telomeric DNA damage but also mitochondrial dysfunction, resulting in T cell apoptotic death. Conversely, targeted 1 O2 formation at mitochondria induced not only mitochondrial injury but also telomeric DNA damage, leading to cellular crisis and apoptosis. Targeted oxidative stress at either telomeres or mitochondria increased ROS production, whereas blocking ROS formation during oxidative stress reversed the telomeric injury, mitochondrial dysfunction, and cellular apoptosis. Notably, the X-ray repair cross-complementing protein 1 (XRCC1) in the base excision repair (BER) pathway and multiple mitochondrial proteins in other cellular pathways were dysregulated by the targeted oxidative stress. By confining singlet 1 O2 formation to a single organelle, this study suggests that oxidative stress induces dual injury in T cells via crosstalk between telomeres and mitochondria. Further identification of these oxidation pathways may offer a novel approach to preserve mitochondrial functions, protect telomere integrity, and maintain T cell survival, which can be exploited to combat various immune aging-associated diseases.
--- ABSTRACT END ---
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(1)68 *null* (11)8 including (21)3 (e.g., (31)3 within
(2)62 and (12)6 from (22)3 D (32)2 approach
(3)26 of (13)6 was (23)3 also (33)2 be
(4)24 (ROS) (14)5 has (24)3 by (34)2 but
(5)20 in (15)5 to (25)3 can (35)2 distribution
(6)13 that (16)5 we (26)3 may (36)2 have
(7)11 with (17)4 (ROS), (27)3 or (37)2 identification
(8)10 differences (18)4 as (28)3 production (38)2 level
(9)9 were (19)4 difference (29)3 the (39)2 such
(10)8 are (20)4 is (30)3 which

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--- WordNet output for species --- =>人類, 種, 種類 Overview of noun species The noun species has 2 senses (first 2 from tagged texts) 1. (27) species -- ((biology) taxonomic group whose members can interbreed) 2. (5) species -- (a specific kind of something; "a species of molecule"; "a species of villainy") Overview of noun specie The noun specie has 1 sense (no senses from tagged texts) 1. coinage, mintage, specie, metal money -- (coins collectively) --- WordNet end ---