ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for species out of >500 occurrences
321753 occurrences (No.65 in the rank) during 5 years in the PubMed. [no cache] 500 found
19) In animals capable of synthesizing Neu5Gc, most tissues and cell types express both sialic acids, in proportions that vary between species.
--- ABSTRACT ---
PMID:23471785 DOI:10.1007/128_2013_419
2015 Topics in current chemistry
* Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain?
- The sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) differ by a single oxygen atom and are widely found at the terminal position of glycans on vertebrate cell surfaces. In animals capable of synthesizing Neu5Gc, most tissues and cell types express both sialic acids, in proportions that vary between species. However, it has long been noted that Neu5Gc is consistently expressed at trace to absent levels in the brains of all vertebrates studied to date. Although several reports have claimed to find low levels of Neu5Gc-containing glycans in neural tissue, no study definitively excludes the possibility of contamination with glycans from non-neural cell types. This distribution of a molecule - prominently but variably expressed in extraneural tissues but very low or absent in the brain - is, to our knowledge, unique. The evolutionarily conserved brain-specific suppression of Neu5Gc may indicate that its presence is toxic to this organ; however, no studies to date have directly addressed this very interesting question. Here we provide a historical background to this issue and discuss potential mechanisms causing the suppression of Neu5Gc expression in brain tissue, as well as mechanisms by which Neu5Gc may exert the presumed toxicity. Finally, we discuss future approaches towards understanding the mechanisms and implications of this unusual finding.
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(1)93 *null* (11)7 but (21)3 can (31)2 for
(2)46 of (12)7 with (22)3 could (32)2 found
(3)34 in (13)6 identification (23)3 differences (33)2 generated
(4)31 and (14)5 determination (24)3 have (34)2 identification,
(5)19 (ROS) (15)5 that (25)3 level (35)2 including
(6)18 were (16)4 as (26)3 may (36)2 phytotoxicity
(7)12 is (17)4 or (27)2 (ROS), (37)2 rather
(8)10 are (18)4 to (28)2 (overall (38)2 such
(9)9 from (19)4 which (29)2 M
(10)9 was (20)3 AEJ-89 (30)2 along

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--- WordNet output for species --- =>人類, 種, 種類 Overview of noun species The noun species has 2 senses (first 2 from tagged texts) 1. (27) species -- ((biology) taxonomic group whose members can interbreed) 2. (5) species -- (a specific kind of something; "a species of molecule"; "a species of villainy") Overview of noun specie The noun specie has 1 sense (no senses from tagged texts) 1. coinage, mintage, specie, metal money -- (coins collectively) --- WordNet end ---