ELIZA

return kwic search for specific out of >500 occurrences
279736 occurrences (No.90 in the rank) during 5 years in the PubMed. [cache]

131) Responding lymphocyte populations correlated with eventual SARS-CoV-2 IgG and a donor lacking these cell populations failed to sustain SARS-CoV-2-specific antibodies and experienced breakthrough infection.

--- ABSTRACT ---

PMID:34341788 DOI:10.1101/2021.07.28.453981

2021 bioRxiv : the preprint server for biology

* Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine.

- RNA-based vaccines against SARS-CoV-2 are critical to limiting COVID-19 severity and spread. Cellular mechanisms driving antigen-specific responses to these vaccines, however, remain uncertain. We used single-cell technologies to identify and characterized antigen-specific cells and antibody responses to the RNA vaccine BNT162b2 in longitudinal samples from a cohort of healthy donors. Mass cytometry and machine learning pinpointed a novel expanding, population of antigen-specific non-canonical memory CD4 ⁺ and CD8 ⁺ T cells. B cell sequencing suggested progression from IgM, with apparent cross-reactivity to endemic coronaviruses, to SARS-CoV-2-specific IgA and IgG memory B cells and plasmablasts. Responding lymphocyte populations correlated with eventual SARS-CoV-2 IgG and a donor lacking these cell populations failed to sustain SARS-CoV-2-specific antibodies and experienced breakthrough infection. These integrated proteomic and genomic platforms reveal an antigen-specific cellular basis of RNA vaccine-based immunity.

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[frequency of next (right) word to specific]

(1)18 to	(21)3 for	(41)2 food	(61)2 or
(2)11 and	(22)3 genes	(42)2 foods	(62)2 parameters
(3)8 focus	(23)3 genetic	(43)2 gene	(63)2 patient
(4)7 vulnerability	(24)3 marker	(44)2 granule	(64)2 physical
(5)6 effects	(25)3 mechanisms	(45)2 group	(65)2 proteases
(6)6 factors	(26)3 proteins	(46)2 groups	(66)2 research
(7)5 recommendations	(27)2 GC	(47)2 immune	(67)2 responses
(8)4 IgA	(28)2 N3FA	(48)2 in	(68)2 risk
(9)4 aspects	(29)2 PHC	(49)2 information	(69)2 sensitization
(10)4 cancer	(30)2 antibodies	(50)2 interventional	(70)2 siRNA
(11)4 components	(31)2 antigens	(51)2 interventions	(71)2 social
(12)4 inhibitor	(32)2 area	(52)2 issues	(72)2 spatial
(13)4 population	(33)2 attention	(53)2 knockout	(73)2 study
(14)3 T	(34)2 binding	(54)2 mental	(74)2 target
(15)3 brain	(35)2 biological	(55)2 microbial	(75)2 terms
(16)3 cell	(36)2 biomarkers	(56)2 molecular	(76)2 topics
(17)3 changes	(37)2 cellular	(57)2 mortality	(77)2 treatment
(18)3 counseling	(38)2 clinical	(58)2 mutations	(78)2 type
(19)3 deletion	(39)2 emphasis	(59)2 needs
(20)3 differences	(40)2 factors,	(60)2 online

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--- WordNet output for specific --- =>特有の, 特効薬, 明確な, 特定の, 種の, はっきりした Overview of noun specific The noun specific has 2 senses (no senses from tagged texts) 1. particular, specific -- (a fact about some part (as opposed to general); "he always reasons from the particular to the general") 2. specific -- (a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria") Overview of adj specific The adj specific has 4 senses (first 2 from tagged texts) 1. (39) specific -- ((sometimes followed by `to') applying to or characterized by or distinguishing something particular or special or unique; "rules with specific application"; "demands specific to the job"; "a specific and detailed account of the accident") 2. (5) specific -- (stated explicitly or in detail; "needed a specific amount") 3. specific -- (relating to or distinguishing or constituting a taxonomic species; "specific characters") 4. specific -- (being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements") --- WordNet end ---