* Inflammaging and proteases in abdominal aortic aneurysm.
- Abdominal aortic aneurysm (AAA) is an age-related disease resulting in aortic wall weakening and dilatation which may progress to the fatal point of abrupt aortic wall rupture. Chronic inflammation is a driving force in the pathogenesis of AAA and extracellular matrix (ECM) proteases are considered central to aortic wall degradation. Considerable effort is dedicated to identifying the proteases responsible as well as the mechanism by which these proteases contribute to disease progression. As such, they are considered important molecular targets for pharmacological intervention. Along with smoking, male gender and family history, aging is a major risk factor for AAA. Examination of age-related changes of the immune system reveals an interwoven relationship between the processes of aging and chronic inflammation, collectively predisposing to AAA development. The present review explores current evidence as to the role of specific ECM proteases in AAA pathogenesis. The contribution of the aging process to disease pathogenesis is also explored to provide the relevant context and highlight key molecular pathways that should be considered while attempting to develop effective treatment approaches.
=>特有の, 特効薬, 明確な, 特定の, 種の, はっきりした
Overview of noun specific
The noun specific has 2 senses (no senses from tagged texts)
1. particular, specific -- (a fact about some part (as opposed to general); "he always reasons from
the particular to the general")
2. specific -- (a medicine that has a mitigating effect on a specific disease; "quinine is a
specific for malaria")
Overview of adj specific
The adj specific has 4 senses (first 2 from tagged texts)
1. (39) specific -- ((sometimes followed by `to') applying to or characterized by or distinguishing
something particular or special or unique; "rules with specific application"; "demands specific to
the job"; "a specific and detailed account of the accident")
2. (5) specific -- (stated explicitly or in detail; "needed a specific amount")
3. specific -- (relating to or distinguishing or constituting a taxonomic species; "specific
characters")
4. specific -- (being or affecting a disease produced by a particular microorganism or condition;
used also of stains or dyes used in making microscope slides; "quinine is highly specific for
malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular
structural elements")
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