ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for specific out of >500 occurrences
279736 occurrences (No.90 in the rank) during 5 years in the PubMed. [no cache] 500 found
33) If medically relevant nanoparticles can cross specific cell barriers they may disseminate through the body beyond the original target and may reach particularly sensitive areas such as the foetus.
--- ABSTRACT ---
PMID:23927440 DOI:10.3109/17435390.2013.833317
2015 Nanotoxicology
* The toxicity, transport and uptake of nanoparticles in the in vitro BeWo b30 placental cell barrier model used within NanoTEST.
- Despite the rapid ongoing expansion in the use of nanomaterials, we still know little about their biological interaction and biodistribution within the human body. If medically relevant nanoparticles can cross specific cell barriers they may disseminate through the body beyond the original target and may reach particularly sensitive areas such as the foetus. This study utilised an in vitro barrier model of the placenta to explore toxicity, uptake and transport of iron oxide and silica nanoparticles. The findings indicate that these nanoparticles can transfer extensively across the placental barrier model but physico-chemical characteristics such as surface chemistry impact upon both uptake and transport. Iron oxide cytotoxicity was evident at lower doses and shorter exposure compared with silica and may be of clinical relevance. In vivo correlation of in vitro findings is essential but in vitro models may provide worst case-exposure estimates to help reduce the amount of testing required.
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(1)15 to (19)4 types (37)2 attention (55)2 lineages
(2)9 sequence (20)3 characteristics (38)2 barriers (56)2 measures
(3)7 and (21)3 features (39)2 computational (57)2 miRNAs
(4)7 cell (22)3 job (40)2 constitutive (58)2 molecular
(5)7 variations (23)3 target (41)2 criteria (59)2 neuronal
(6)6 cognitive (24)3 tendon (42)2 deficits (60)2 or
(7)6 genes (25)3 therapy (43)2 differences (61)2 parameters
(8)6 surface (26)3 type (44)2 divergence (62)2 phytotoxicity
(9)5 antibodies (27)3 variation (45)2 effect (63)2 polymerase
(10)5 for (28)2 *null* (46)2 elements (64)2 primers
(11)5 phobias (29)2 ECM (47)2 ethnocultural (65)2 protein
(12)4 brain (30)2 IgG (48)2 extracellular (66)2 proteins
(13)4 effects (31)2 PCR (49)2 fault (67)2 recommendations
(14)4 growth (32)2 age-dependent (50)2 function (68)2 requirements
(15)4 incidence (33)2 analysis (51)2 genetic (69)2 self-efficacy
(16)4 manner (34)2 antigen (52)2 genomic (70)2 targeted
(17)4 motor (35)2 antigens (53)2 information (71)2 tests
(18)4 needs (36)2 approach (54)2 inhibitors

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--- WordNet output for specific --- =>特有の, 特効薬, 明確な, 特定の, 種の, はっきりした Overview of noun specific The noun specific has 2 senses (no senses from tagged texts) 1. particular, specific -- (a fact about some part (as opposed to general); "he always reasons from the particular to the general") 2. specific -- (a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria") Overview of adj specific The adj specific has 4 senses (first 2 from tagged texts) 1. (39) specific -- ((sometimes followed by `to') applying to or characterized by or distinguishing something particular or special or unique; "rules with specific application"; "demands specific to the job"; "a specific and detailed account of the accident") 2. (5) specific -- (stated explicitly or in detail; "needed a specific amount") 3. specific -- (relating to or distinguishing or constituting a taxonomic species; "specific characters") 4. specific -- (being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements") --- WordNet end ---