ELIZA

return kwic search for specific out of >500 occurrences
279736 occurrences (No.90 in the rank) during 5 years in the PubMed. [cache]

63) L4 burden, 68% lower in RG than in SG, was influenced by the specific IgA in gastric mucus and the number of γδ T cells.

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PMID:33179152 DOI:10.1007/s00436-020-06953-4

2021 Parasitology research

* Differences within Churra breed sheep in the early immune response to the infection by Teladorsagia circumcincta.

- This study describes early immunological mechanisms that underlie resistance to Teladorsagia circumcincta infection in adult Churra sheep. After a first experimental infection, 6 animals were classified as resistant (RG) and 6 as susceptible (SG) to T. circumcincta infection based on their cumulative faecal egg count (cFEC) at the end of the infection. RG showed higher IgA levels against somatic antigen of T. circumcincta fourth-larvae stage (L4) in serum at day 3 post-infection (pi) (p < 0.05) and close to significance at day 21 pi (p = 0.06). Moreover, a strong negative correlation between cFEC and specific IgA was only significant in RG at day 3 pi (r = - 0.870; p < 0.05), but absent in SG. At the end of this infection, sheep were treated with moxidectin and infected again 3 weeks later to be slaughtered at day 7 pi. At necropsy, the specific IgA levels in gastric mucosa were similar between groups; the absence differences at day 7 pi could be due to a previous increase in the IgA response, probably around day 3 pi, as described during the first infection. L4 burden, 68% lower in RG than in SG, was influenced by the specific IgA in gastric mucus and the number of γδ T cells. RG group showed a positive correlation between γδ T cells and eosinophils (r = 0.900; p = 0.037); however, this correlation was not found in SG. These results show that these two phenotypes show different early immune response pattern to T. circumcincta infection in Churra sheep.

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[frequency of next (right) word to specific]

(1)18 to	(21)3 for	(41)2 food	(61)2 or
(2)11 and	(22)3 genes	(42)2 foods	(62)2 parameters
(3)8 focus	(23)3 genetic	(43)2 gene	(63)2 patient
(4)7 vulnerability	(24)3 marker	(44)2 granule	(64)2 physical
(5)6 effects	(25)3 mechanisms	(45)2 group	(65)2 proteases
(6)6 factors	(26)3 proteins	(46)2 groups	(66)2 research
(7)5 recommendations	(27)2 GC	(47)2 immune	(67)2 responses
(8)4 IgA	(28)2 N3FA	(48)2 in	(68)2 risk
(9)4 aspects	(29)2 PHC	(49)2 information	(69)2 sensitization
(10)4 cancer	(30)2 antibodies	(50)2 interventional	(70)2 siRNA
(11)4 components	(31)2 antigens	(51)2 interventions	(71)2 social
(12)4 inhibitor	(32)2 area	(52)2 issues	(72)2 spatial
(13)4 population	(33)2 attention	(53)2 knockout	(73)2 study
(14)3 T	(34)2 binding	(54)2 mental	(74)2 target
(15)3 brain	(35)2 biological	(55)2 microbial	(75)2 terms
(16)3 cell	(36)2 biomarkers	(56)2 molecular	(76)2 topics
(17)3 changes	(37)2 cellular	(57)2 mortality	(77)2 treatment
(18)3 counseling	(38)2 clinical	(58)2 mutations	(78)2 type
(19)3 deletion	(39)2 emphasis	(59)2 needs
(20)3 differences	(40)2 factors,	(60)2 online

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--- WordNet output for specific --- =>特有の, 特効薬, 明確な, 特定の, 種の, はっきりした Overview of noun specific The noun specific has 2 senses (no senses from tagged texts) 1. particular, specific -- (a fact about some part (as opposed to general); "he always reasons from the particular to the general") 2. specific -- (a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria") Overview of adj specific The adj specific has 4 senses (first 2 from tagged texts) 1. (39) specific -- ((sometimes followed by `to') applying to or characterized by or distinguishing something particular or special or unique; "rules with specific application"; "demands specific to the job"; "a specific and detailed account of the accident") 2. (5) specific -- (stated explicitly or in detail; "needed a specific amount") 3. specific -- (relating to or distinguishing or constituting a taxonomic species; "specific characters") 4. specific -- (being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements") --- WordNet end ---