ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for studies out of >500 occurrences
532339 occurrences (No.23 in the rank) during 5 years in the PubMed. [no cache] 500 found
13) Previous studies have demonstrated genetic variation among different ethnic groups in the epidermal growth factor receptor (EGFR) in NSCLC.
--- ABSTRACT ---
PMID:22246415 DOI:10.1177/0962280211434179
2015 Statistical methods in medical research
* Simpson's paradox - aggregating and partitioning populations in health disparities of lung cancer patients.
- It is well known that non-small cell lung cancer (NSCLC) is a heterogeneous group of diseases. Previous studies have demonstrated genetic variation among different ethnic groups in the epidermal growth factor receptor (EGFR) in NSCLC. Research by our group and others has recently shown a lower frequency of EGFR mutations in African Americans with NSCLC, as compared to their White counterparts. In this study, we use our original study data of EGFR pathway genetics in African American NSCLC as an example to illustrate that univariate analyses based on aggregation versus partition of data leads to contradictory results, in order to emphasize the importance of controlling statistical confounding. We further investigate analytic approaches in logistic regression for data with separation, as is the case in our example data set, and apply appropriate methods to identify predictors of EGFR mutation. Our simulation shows that with separated or nearly separated data, penalized maximum likelihood (PML) produces estimates with smallest bias and approximately maintains the nominal value with statistical power equal to or better than that from maximum likelihood and exact conditional likelihood methods. Application of the PML method in our example data set shows that race and EGFR-FISH are independently significant predictors of EGFR mutation.
--- ABSTRACT END ---
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(1)61 have (14)8 with (27)3 demonstrate (40)2 including
(2)47 *null* (15)7 should (28)3 for (41)2 indicated
(3)32 of (16)6 is (29)3 however, (42)2 investigating
(4)26 are (17)6 we (30)3 performed (43)2 involving
(5)26 on (18)5 suggest (31)3 reported (44)2 it
(6)19 in (19)5 the (32)3 since (45)2 or
(7)17 were (20)4 as (33)3 which (46)2 provide
(8)16 and (21)4 demonstrated (34)2 about (47)2 published
(9)15 to (22)4 evaluating (35)2 also (48)2 regarding
(10)10 showed (23)4 from (36)2 can (49)2 targeting
(11)8 revealed (24)4 indicate (37)2 concerning (50)2 tested
(12)8 that (25)4 show (38)2 demonstrating (51)2 used
(13)8 using (26)3 based (39)2 has (52)2 was

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--- WordNet output for studies --- Overview of noun study The noun study has 10 senses (first 8 from tagged texts) 1. (90) survey, study -- (a detailed critical inspection) 2. (17) study, work -- (applying the mind to learning and understanding a subject (especially by reading); "mastering a second language requires a lot of work"; "no schools offer graduate study in interior design") 3. (6) report, study, written report -- (a written document describing the findings of some individual or group; "this accords with the recent study by Hill and Dale") 4. (6) study -- (a state of deep mental absorption; "she is in a deep study") 5. (6) study -- (a room used for reading and writing and studying; "he knocked lightly on the closed door of the study") 6. (3) discipline, subject, subject area, subject field, field, field of study, study, bailiwick -- (a branch of knowledge; "in what discipline is his doctorate?"; "teachers should be well trained in their subject"; "anthropology is the study of human beings") 7. (2) sketch, study -- (preliminary drawing for later elaboration; "he made several studies before starting to paint") 8. (1) cogitation, study -- (attentive consideration and meditation; "after much cogitation he rejected the offer") 9. study -- (someone who memorizes quickly and easily (as the lines for a part in a play); "he is a quick study") 10. study -- (a composition intended to develop one aspect of the performer's technique; "a study in spiccato bowing") Overview of verb study The verb study has 6 senses (first 6 from tagged texts) 1. (73) analyze, analyse, study, examine, canvass, canvas -- (consider in detail and subject to an analysis in order to discover essential features or meaning; "analyze a sonnet by Shakespeare"; "analyze the evidence in a criminal trial"; "analyze your real motives") 2. (17) study -- (be a student; follow a course of study; be enrolled at an institute of learning) 3. (15) study, consider -- (give careful consideration to; "consider the possibility of moving") 4. (13) learn, study, read, take -- (be a student of a certain subject; "She is reading for the bar exam") 5. (5) study, hit the books -- (learn by reading books; "He is studying geology in his room"; "I have an exam next week; I must hit the books now") 6. (2) study, meditate, contemplate -- (think intently and at length, as for spiritual purposes; "He is meditating in his study") --- WordNet end ---