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238) Several studies and recent meta-analyses indicate that in schizophrenia the catecholamine-O-methyltransferase (COMT) Val158Met genotype may be associated with aggression, most often in methionine allele carriers.
* Val158Met COMT polymorphism and risk of aggression in alcohol dependence.
- Aggression, violence and antisocial behavior are common in alcoholism, but their biological basis is poorly understood. Several studies and recent meta-analyses indicate that in schizophrenia the catecholamine-O-methyltransferase (COMT) Val158Met genotype may be associated with aggression, most often in methionine allele carriers. We tested this hypothesis in a sample of treatment-seeking alcohol-dependent in-patients (293 German patients and 499 controls, and additional 190 Polish patients as replication sample). As expected, patients with a history of violent or non-violent crime were more often male, had an earlier onset of alcoholism and more withdrawal seizures and delirium tremens, and were more likely to have a history of suicide attempts. COMT genotype was not associated with a history of violent or non-violent crime. More studies are needed on the neurobiological basis of aggression and violence in alcoholism.
Overview of noun study
The noun study has 10 senses (first 8 from tagged texts)
1. (90) survey, study -- (a detailed critical inspection)
2. (17) study, work -- (applying the mind to learning and understanding a subject (especially by
reading); "mastering a second language requires a lot of work"; "no schools offer graduate study in
interior design")
3. (6) report, study, written report -- (a written document describing the findings of some
individual or group; "this accords with the recent study by Hill and Dale")
4. (6) study -- (a state of deep mental absorption; "she is in a deep study")
5. (6) study -- (a room used for reading and writing and studying; "he knocked lightly on the closed
door of the study")
6. (3) discipline, subject, subject area, subject field, field, field of study, study, bailiwick --
(a branch of knowledge; "in what discipline is his doctorate?"; "teachers should be well trained in
their subject"; "anthropology is the study of human beings")
7. (2) sketch, study -- (preliminary drawing for later elaboration; "he made several studies before
starting to paint")
8. (1) cogitation, study -- (attentive consideration and meditation; "after much cogitation he
rejected the offer")
9. study -- (someone who memorizes quickly and easily (as the lines for a part in a play); "he is a
quick study")
10. study -- (a composition intended to develop one aspect of the performer's technique; "a study in
spiccato bowing")
Overview of verb study
The verb study has 6 senses (first 6 from tagged texts)
1. (73) analyze, analyse, study, examine, canvass, canvas -- (consider in detail and subject to an
analysis in order to discover essential features or meaning; "analyze a sonnet by Shakespeare";
"analyze the evidence in a criminal trial"; "analyze your real motives")
2. (17) study -- (be a student; follow a course of study; be enrolled at an institute of learning)
3. (15) study, consider -- (give careful consideration to; "consider the possibility of moving")
4. (13) learn, study, read, take -- (be a student of a certain subject; "She is reading for the bar
exam")
5. (5) study, hit the books -- (learn by reading books; "He is studying geology in his room"; "I
have an exam next week; I must hit the books now")
6. (2) study, meditate, contemplate -- (think intently and at length, as for spiritual purposes; "He
is meditating in his study")
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