ELIZA

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532339 occurrences (No.23 in the rank) during 5 years in the PubMed. [no cache] 500 found

427) Recent progress in generating mouse models with differential ablation of the polysialyltransferases or NCAM revealed the dramatic impact of polysialic acid-negative NCAM on brain development and elaborate electrophysiological studies allowed for new insights into the role of polysialic acid in regulating synaptic plasticity and learning.

--- ABSTRACT ---

PMID:23715636 DOI:10.1007/128_2013_446

2015 Topics in current chemistry

* Polysialic Acid in Brain Development and Synaptic Plasticity.

- Polymers of sialic acid can be produced by pro- and eukaryotic cells. In vertebrates polysialic acid consists of α2,8-linked N-acetylneuraminic acid and is most prominent during nervous system development. Polysialic acid is produced by two complementary sialyltransferases, ST8SiaII and ST8SiaIV. The major, but not the only, carrier of polysialic acid is the neural cell adhesion molecule (NCAM). In this review we highlight how polySia dictates the interactions of various cell types during development and plasticity of the vertebrate central nervous system on different molecular levels. Recent progress in generating mouse models with differential ablation of the polysialyltransferases or NCAM revealed the dramatic impact of polysialic acid-negative NCAM on brain development and elaborate electrophysiological studies allowed for new insights into the role of polysialic acid in regulating synaptic plasticity and learning. The implications of dysregulated polysialylation for brain disease and neuropsychiatric disorders are discussed.

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(2)47 null	(15)7 should	(28)3 for	(41)2 indicated
(3)32 of	(16)6 is	(29)3 however,	(42)2 investigating
(4)26 are	(17)6 we	(30)3 performed	(43)2 involving
(5)26 on	(18)5 suggest	(31)3 reported	(44)2 it
(6)19 in	(19)5 the	(32)3 since	(45)2 or
(7)17 were	(20)4 as	(33)3 which	(46)2 provide
(8)16 and	(21)4 demonstrated	(34)2 about	(47)2 published
(9)15 to	(22)4 evaluating	(35)2 also	(48)2 regarding
(10)10 showed	(23)4 from	(36)2 can	(49)2 targeting
(11)8 revealed	(24)4 indicate	(37)2 concerning	(50)2 tested
(12)8 that	(25)4 show	(38)2 demonstrating	(51)2 used
(13)8 using	(26)3 based	(39)2 has	(52)2 was

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--- WordNet output for studies --- Overview of noun study The noun study has 10 senses (first 8 from tagged texts) 1. (90) survey, study -- (a detailed critical inspection) 2. (17) study, work -- (applying the mind to learning and understanding a subject (especially by reading); "mastering a second language requires a lot of work"; "no schools offer graduate study in interior design") 3. (6) report, study, written report -- (a written document describing the findings of some individual or group; "this accords with the recent study by Hill and Dale") 4. (6) study -- (a state of deep mental absorption; "she is in a deep study") 5. (6) study -- (a room used for reading and writing and studying; "he knocked lightly on the closed door of the study") 6. (3) discipline, subject, subject area, subject field, field, field of study, study, bailiwick -- (a branch of knowledge; "in what discipline is his doctorate?"; "teachers should be well trained in their subject"; "anthropology is the study of human beings") 7. (2) sketch, study -- (preliminary drawing for later elaboration; "he made several studies before starting to paint") 8. (1) cogitation, study -- (attentive consideration and meditation; "after much cogitation he rejected the offer") 9. study -- (someone who memorizes quickly and easily (as the lines for a part in a play); "he is a quick study") 10. study -- (a composition intended to develop one aspect of the performer's technique; "a study in spiccato bowing") Overview of verb study The verb study has 6 senses (first 6 from tagged texts) 1. (73) analyze, analyse, study, examine, canvass, canvas -- (consider in detail and subject to an analysis in order to discover essential features or meaning; "analyze a sonnet by Shakespeare"; "analyze the evidence in a criminal trial"; "analyze your real motives") 2. (17) study -- (be a student; follow a course of study; be enrolled at an institute of learning) 3. (15) study, consider -- (give careful consideration to; "consider the possibility of moving") 4. (13) learn, study, read, take -- (be a student of a certain subject; "She is reading for the bar exam") 5. (5) study, hit the books -- (learn by reading books; "He is studying geology in his room"; "I have an exam next week; I must hit the books now") 6. (2) study, meditate, contemplate -- (think intently and at length, as for spiritual purposes; "He is meditating in his study") --- WordNet end ---