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331253 occurrences (No.58 in the rank) during 5 years in the PubMed. [cache]

153) These outcomes outline the high robustness of the NanoZyme sensing system for direct detection of glucose in human urine.

--- ABSTRACT ---

PMID:33399880 DOI:10.1007/s00216-020-03090-w

2021 Analytical and bioanalytical chemistry

* Non-invasive detection of glucose in human urine using a color-generating copper NanoZyme.

- Renal complications are long-term effect of diabetes mellitus where glucose is excreted in urine. Therefore, reliable glucose detection in urine is critical. While commercial urine strips offer a simple way to detect urine sugar, poor sensitivity and low reliability limit their use. A hybrid glucose oxidase (GOx)/horseradish peroxidase (HRP) assay remains the gold standard for pathological detection of glucose. A key restriction is poor stability of HRP and its suicidal inactivation by hydrogen peroxide, a key intermediate of the GOx-driven reaction. An alternative is to replace HRP with a robust inorganic enzyme-mimic or NanoZyme. While colloidal NanoZymes show promise in glucose sensing, they detect low concentrations of glucose, while urine has high (mM) glucose concentration. In this study, a free-standing copper NanoZyme is used for the colorimetric detection of glucose in human urine. The sensor could operate in a biologically relevant dynamic linear range of 0.5-15 mM, while showing minimal sample matrix effect such that glucose could be detected in urine without significant sample processing or dilution. This ability could be attributed to the Cu NanoZyme that for the first time showed an ability to promote the oxidation of a TMB substrate to its double oxidation diimine product rather than the charge-transfer complex product commonly observed. Additionally, the sensor could operate at a single pH without the need to use different pH conditions as used during the gold standard assay. These outcomes outline the high robustness of the NanoZyme sensing system for direct detection of glucose in human urine. Graphical abstract.

--- ABSTRACT END ---

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(1)71 null	(13)6 the	(25)3 incorporating	(37)2 being
(2)44 and	(14)6 which	(26)3 level	(38)2 but
(3)17 is	(15)5 has	(27)3 may	(39)2 devices
(4)17 to	(16)4 by	(28)3 using	(40)2 especially
(5)12 for	(17)4 should	(29)3 we	(41)2 genes
(6)12 in	(18)4 were	(30)2 (CNS),	(42)2 identified
(7)12 of	(19)4 with	(31)2 (ECS)	(43)2 including
(8)7 are	(20)3 as	(32)2 (GIS)	(44)2 it
(9)7 that	(21)3 barriers	(33)2 (SNS)	(45)2 levels
(10)7 was	(22)3 can	(34)2 Online	(46)2 remains
(11)6 (CNS)	(23)3 could	(35)2 acts	(47)2 seems
(12)6 group	(24)3 factors	(36)2 becomes	(48)2 throughout

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--- WordNet output for system --- =>制度組織体系的方式, システム, 組織, 整然とした手順, (思想などの)体系, 体制 Overview of noun system The noun system has 9 senses (first 8 from tagged texts) 1. (43) system -- (instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer") 2. (23) system, scheme -- (a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going") 3. (14) system -- ((physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide") 4. (10) system, system of rules -- (a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender") 5. (8) arrangement, organization, organisation, system -- (an organized structure for arranging or classifying; "he changed the arrangement of the topics"; "the facts were familiar but it was in the organization of them that he was original"; "he tried to understand their system of classification") 6. (7) system -- (a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion") 7. (6) system -- (a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation") 8. (1) system -- (the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system") 9. organization, organisation, system -- (an ordered manner; orderliness by virtue of being methodical and well organized; "his compulsive organization was not an endearing quality"; "we can't do it unless we establish some system around here") --- WordNet end ---