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271290 occurrences (No.96 in the rank) during 5 years in the PubMed. [no cache] 500 found

152) There is considerable evidence indicating that some of the somatic alterations occurring during carcinogenesis in humans also involve the same processes as those observed in mice.

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PMID:24115114 DOI:10.1002/mc.22085

2015 Molecular carcinogenesis

* Genome-wide screening of aberrant DNA methylation which associated with gene expression in mouse skin cancers.

- Epigenetic alteration of genomic DNA is a common and key process in carcinogenesis. There is considerable evidence indicating that some of the somatic alterations occurring during carcinogenesis in humans also involve the same processes as those observed in mice. Therefore, we analyzed mouse skin cancer tissues induced by the 2-stage carcinogenesis model to identify skin tumor-specific differentially methylated regions (ST-DMRs) during the multistep carcinogenesis process. We have previously identified ST-DMRs using the restriction landmark genomic scanning (RLGS) technique and reported that some of the mouse ST-DMRs were also epigenetically modified in human cancers, such as melanoma, neuroblastoma, and brain tumor. These results encouraged us to pursue global methylation screening in mouse skin carcinogenesis. Using the methylated DNA immunoprecipitation (MeDIP) method combined with the NimbleGen promoter plus CpG island (CpGi) array, we identified 615 ST-DMRs. In combination with global gene expression analysis, 91 of these ST-DMRs were shown to be located on or around the genes differentially expressed between normal skin and tumor tissues, including a candidate human tumor suppressor gene Tfap2e. As observed in human colorectal cancers, Tfap2e was methylated at a CpGi located in intron 3 and downregulated in skin tumors. Our results identified aberrant methylated regions that were associated with gene expression regulation during carcinogenesis, which may indicate critical genetic regions also involved in human carcinogenesis. © 2013 Wiley Periodicals, Inc.

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(1)138 was	(4)83 are	(7)4 null	(10)2 appears
(2)132 is	(5)20 have	(8)3 exists	(11)2 exist
(3)86 were	(6)18 has	(9)3 may

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--- WordNet output for there --- =>1.その場所で, そこに(で), そこへ, 2.〜がある, その場所で Overview of noun there The noun there has 1 sense (no senses from tagged texts) 1. there -- (a location other than here; that place; "you can take it from there") Overview of adv there The adv there has 3 senses (first 3 from tagged texts) 1. (181) there, at that place, in that location -- (in or at that place; "they have lived there for years"; "it's not there"; "that man there") 2. (6) there, in that respect, on that point -- (in that matter; "I agree with you there") 3. (2) there, thither -- (to or toward that place; away from the speaker; "go there around noon!") --- WordNet end ---