ELIZA

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271290 occurrences (No.96 in the rank) during 5 years in the PubMed. [no cache] 500 found

459) Many HTLV-1-positive patients with RA are assumed to exist; however, there have thus far been no reports on the effect of anti-TNF biologics on HTLV-1-positive patients.

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PMID:24252020 DOI:10.3109/14397595.2013.844389

2015 Modern rheumatology

* Use of anti-tumor necrosis factor biologics in the treatment of rheumatoid arthritis does not change human T-lymphotropic virus type 1 markers: a case series.

- Anti-tumor necrosis factor (anti-TNF) biologics are effective in the treatment of rheumatoid arthritis (RA); however, it is still not clear whether this treatment promotes the development of malignancies such as lymphoma. Human T-lymphotropic virus type 1 (HTLV-1), which is a causative agent of adult T-cell lymphoma (ATL), is prevalent in Japan. Many HTLV-1-positive patients with RA are assumed to exist; however, there have thus far been no reports on the effect of anti-TNF biologics on HTLV-1-positive patients. We analyzed the response to treatment with anti-TNF biologics and change of HTLV-1 markers in two cases of RA. The two cases showed no response based on the European League Against of Rheumatism response criteria 60-96 weeks after administration of anti-TNF biologics (infliximab and etanercept). No signs of ATL were observed and HTLV-1 markers, such as proviral load and clonality of HTLV-1-infected cells, showed no significant change in either of two cases. Therefore, treatment with anti-TNF biologics did not induce activation of HTLV-1, although the effect on RA was not as effective as in HTLV-1-negative patients in this limited study. Further long-term study with a greater number of patients is necessary to clarify the safety and efficacy of anti-TNF biologics in HTLV-1-positive patients with RA.

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[frequency of next (right) word to there]

(1)138 was	(4)83 are	(7)4 null	(10)2 appears
(2)132 is	(5)20 have	(8)3 exists	(11)2 exist
(3)86 were	(6)18 has	(9)3 may

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--- WordNet output for there --- =>1.その場所で, そこに(で), そこへ, 2.〜がある, その場所で Overview of noun there The noun there has 1 sense (no senses from tagged texts) 1. there -- (a location other than here; that place; "you can take it from there") Overview of adv there The adv there has 3 senses (first 3 from tagged texts) 1. (181) there, at that place, in that location -- (in or at that place; "they have lived there for years"; "it's not there"; "that man there") 2. (6) there, in that respect, on that point -- (in that matter; "I agree with you there") 3. (2) there, thither -- (to or toward that place; away from the speaker; "go there around noon!") --- WordNet end ---