ELIZA

return kwic search for there out of >500 occurrences
271290 occurrences (No.96 in the rank) during 5 years in the PubMed. [cache]

482) While considerable work has measured the average connectivity of several interneuron classes, there remains a fundamental lack of understanding of the connectivity distribution of distinct inhibitory cell types with synaptic resolution, how it relates to properties of target cells, and how it affects function.

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PMID:34851292 DOI:10.7554/eLife.73783

2021 eLife

* Structure and function of axo-axonic inhibition.

- Inhibitory neurons in mammalian cortex exhibit diverse physiological, morphological, molecular, and connectivity signatures. While considerable work has measured the average connectivity of several interneuron classes, there remains a fundamental lack of understanding of the connectivity distribution of distinct inhibitory cell types with synaptic resolution, how it relates to properties of target cells, and how it affects function. Here, we used large-scale electron microscopy and functional imaging to address these questions for chandelier cells in layer 2/3 of the mouse visual cortex. With dense reconstructions from electron microscopy, we mapped the complete chandelier input onto 153 pyramidal neurons. We found that synapse number is highly variable across the population and is correlated with several structural features of the target neuron. This variability in the number of axo-axonic ChC synapses is higher than the variability seen in perisomatic inhibition. Biophysical simulations show that the observed pattern of axo-axonic inhibition is particularly effective in controlling excitatory output when excitation and inhibition are co-active. Finally, we measured chandelier cell activity in awake animals using a cell-type-specific calcium imaging approach and saw highly correlated activity across chandelier cells. In the same experiments, in vivo chandelier population activity correlated with pupil dilation, a proxy for arousal. Together, these results suggest that chandelier cells provide a circuit-wide signal whose strength is adjusted relative to the properties of target neurons.

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(1)242 is	(3)68 was	(5)26 has	(7)5 remains
(2)84 are	(4)49 were	(6)9 have	(8)3 appears

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--- WordNet output for there --- =>1.その場所で, そこに(で), そこへ, 2.〜がある, その場所で Overview of noun there The noun there has 1 sense (no senses from tagged texts) 1. there -- (a location other than here; that place; "you can take it from there") Overview of adv there The adv there has 3 senses (first 3 from tagged texts) 1. (181) there, at that place, in that location -- (in or at that place; "they have lived there for years"; "it's not there"; "that man there") 2. (6) there, in that respect, on that point -- (in that matter; "I agree with you there") 3. (2) there, thither -- (to or toward that place; away from the speaker; "go there around noon!") --- WordNet end ---