ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for through out of >500 occurrences
437431 occurrences (No.38 in the rank) during 5 years in the PubMed. [cache]
229) We show that SUPT6H is required for estrogen-regulated transcription and the maintenance of chromatin structure in breast cancer cells, possibly in part through interaction with RNF40 and regulation of histone H2B monoubiquitination (H2Bub1).
* SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.
- The estrogen receptor alpha (ERα) is the central transcriptional regulator of ductal mammary epithelial lineage specification and is an important prognostic marker in human breast cancer. Although antiestrogen therapies are initially highly effective at treating ERα-positive tumors, a large number of tumors progress to a refractory, more poorly differentiated phenotype accompanied by reduced survival. A better understanding of the molecular mechanisms involved in the progression from estrogen-dependent to hormone-resistant breast cancer may uncover new targets for treatment and the discovery of new predictive markers. Recent studies have uncovered an important role for transcriptional elongation and chromatin modifications in controlling ERα activity and estrogen responsiveness. The human Suppressor of Ty Homologue-6 (SUPT6H) is a histone chaperone that links transcriptional elongation to changes in chromatin structure. We show that SUPT6H is required for estrogen-regulated transcription and the maintenance of chromatin structure in breast cancer cells, possibly in part through interaction with RNF40 and regulation of histone H2B monoubiquitination (H2Bub1). Moreover, we demonstrate that SUPT6H protein levels decrease with malignancy in breast cancer. Consistently, SUPT6H, similar to H2Bub1, is required for cellular differentiation and suppression of the repressive histone mark H3K27me3 on lineage-specific genes. Together, these data identify SUPT6H as a new epigenetic regulator of ERα activity and cellular differentiation.
=>直通の, のために, の間じゅう, 終わって, を貫いて, の中を通って, のいたるところに, を通じて
Overview of adj through
The adj through has 2 senses (first 1 from tagged texts)
1. (4) done, through, through with -- (having finished or arrived at completion; "certain to make
history before he's done"; "it's a done deed"; "after the treatment, the patient is through except
for follow-up"; "almost through with his studies")
2. through -- ((of a route or journey etc.) continuing without requiring stops or changes; "a
through street"; "a through bus"; "through traffic")
Overview of adv through
The adv through has 5 senses (first 3 from tagged texts)
1. (5) through -- (from beginning to end; "read this book through")
2. (2) through -- (over the whole distance; "this bus goes through to New York")
3. (1) through -- (to completion; "think this through very carefully!")
4. through -- (in diameter; "this cylinder measures 15 inches through")
5. through, through and through -- (throughout the entire extent; "got soaked through in the rain";
"I'm frozen through"; "a letter shot through with the writer's personality"; "knew him through and
through"; "boards rotten through and through")
--- WordNet end ---