ELIZA

return kwic search for through out of >500 occurrences
437431 occurrences (No.38 in the rank) during 5 years in the PubMed. [cache]

230) Both, with calcium reduction as well as with conductance reduction through gap junctions, SPW-Rs are suppressed.

--- ABSTRACT ---

PMID:34115572 DOI:10.1080/21655979.2021.1936894

2021 Bioengineered

* A computational study of suppression of sharp wave ripple complexes by controlling calcium and gap junctions in pyramidal cells.

- The hippocampus plays a key role in memory formation and learning. According to the concept of active systems memory consolidation, transiently stored memory traces are transferred from the hippocampus into the neocortex for permanent storage. This phenomenon relies on hippocampal network oscillations, particularly sharp wave ripples [SPW-Rs). In this process prior saved data in the hippocampus may be reactivated. Recent investigations reveal that several neurotransmitters and neuromodulators including norepinephrine, acetylcholine, serotonin, etc., suppress SPW-Rs activity in rodents' hippocampal slices. This suppression of SPW-Rs may depend on various presynaptic and postsynaptic parameters including decrease in calcium influx, hyperpolarization/depolarization and alteration in gap junctions' function in pyramidal cells. In this study, we demonstrate the impact of calcium influx and gap junctions on pyramidal cells for the modulation of SPW-Rs in a computational model of CA1.We used,SPW-Rs model with some modifications. SPW-Rs are simulated with gradual reduction of calcium and with decreasing conductance through gap junctions in PCs. Both, with calcium reduction as well as with conductance reduction through gap junctions, SPW-Rs are suppressed. Both effects add up synergistically in combination.

--- ABSTRACT END ---

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[frequency of next (right) word to through]

(1)82 the	(13)3 discussion	(25)2 Google	(37)2 improving
(2)42 a	(14)3 food	(26)2 MEDLINE,	(38)2 induction
(3)8 an	(15)3 information	(27)2 Medline,	(39)2 lipid
(4)8 this	(16)3 inhibition	(28)2 PubMed	(40)2 multiple
(5)7 which	(17)3 its	(29)2 PubMed,	(41)2 nutrition
(6)6 resolution	(18)3 modulation	(30)2 abutment	(42)2 providing
(7)4 October	(19)3 searches	(31)2 analysis	(43)2 reference
(8)4 different	(20)3 several	(32)2 assessment	(44)2 semi-structured
(9)4 various	(21)3 their	(33)2 binding	(45)2 simulation
(10)3 January	(22)3 these	(34)2 dual	(46)2 specific
(11)3 July	(23)2 April	(35)2 gap	(47)2 thematic
(12)3 both	(24)2 August	(36)2 genetic

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--- WordNet output for through --- =>直通の, のために, の間じゅう, 終わって, を貫いて, の中を通って, のいたるところに, を通じて Overview of adj through The adj through has 2 senses (first 1 from tagged texts) 1. (4) done, through, through with -- (having finished or arrived at completion; "certain to make history before he's done"; "it's a done deed"; "after the treatment, the patient is through except for follow-up"; "almost through with his studies") 2. through -- ((of a route or journey etc.) continuing without requiring stops or changes; "a through street"; "a through bus"; "through traffic") Overview of adv through The adv through has 5 senses (first 3 from tagged texts) 1. (5) through -- (from beginning to end; "read this book through") 2. (2) through -- (over the whole distance; "this bus goes through to New York") 3. (1) through -- (to completion; "think this through very carefully!") 4. through -- (in diameter; "this cylinder measures 15 inches through") 5. through, through and through -- (throughout the entire extent; "got soaked through in the rain"; "I'm frozen through"; "a letter shot through with the writer's personality"; "knew him through and through"; "boards rotten through and through") --- WordNet end ---